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Table 2 Internalization efficiency (internalized activity in % of total cellular activity) of [125I]CPCR4.3 (0.1 nM) and the reference [68Ga] Pentixafor (1 nM) in different human cancer cell lines after 60 min at 37 °C. Data are corrected for non-specific binding/internalization in the presence of 100 μM AMD3100. Each experiment was performed in triplicate, and results are means ± SD

From: Validation of [125I]CPCR4.3 as an investigative tool for the sensitive and specific detection of hCXCR4 and mCXCR4 expression in vitro and in vivo

Cell line [125I]CPCR4.3 [% of total] [68Ga] Pentixafor [% of total]
HT-29 45.7 ± 5.5 48.2 ± 7.7
SH-5YSY 65.6 ± 21.9 32.0 ± 6.7
MCF-7 68.4 ± 3.3 29.4 ± 5.7
LNCaP 54.0 ± 15.6 32.2 ± 25.1