From: Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [18F]HX4 PET imaging study in colorectal cancer xenografts
Control
Metformin
Radiotherapy
Combination
P value
Animal weight (g)
28.3 ± 1.6
26.5 ± 0.9
26.3 ± 0.6
26.1 ± 1.3
0.7
Tumor volume (mm3)
307 ± 73
371 ± 72
390 ± 99
402 ± 81
0.8