From: Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [18F]HX4 PET imaging study in colorectal cancer xenografts
Control
Metformin
Radiotherapy
Combination
P value
Animal weight (g)
24.7 ± 0.6
24.2 ± 0.9
24.2 ± 0.5
1.0
Tumor volume (mm3)
382 ± 68
436 ± 79
336 ± 80
389 ± 81
0.7
Baseline [18F]HX4 TBR
2.33 ± 0.34
2.48 ± 0.41
2.78 ± 0.71
2.59 ± 0.46