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Fig. 2 | EJNMMI Research

Fig. 2

From: Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [18F]HX4 PET imaging study in colorectal cancer xenografts

Fig. 2

[18F]HX4 small-animal PET/CT (μPET/CT) imaging results. a [18F]HX4 tumor-to-background ratio (TBR) decreased after metformin (MET) administration (p = 0.04). b Saline (SAL) administration had no influence on tumor hypoxia as measured with [18F]HX4. c Tumor volumes in the metformin cohort significantly increased between the baseline scan and the follow-up scan 24 h later (p = 0.002). d The same significant increase in tumor volume was measured in the saline cohort (p = 0.003). e Representative [18F]HX4 TBR-corrected μPET/CT images of 2 metformin-treated and 2 saline-treated animals before and after metformin administration (coronal view). Arrows indicate tumors. HU, Hounsfield unit

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