Table 4 In vivo biodistribution of ⁶⁸Ga-labeled DOTA-BN peptides in nude mice with MDA-MB-231 tumors at 1 h and 2 h post-injection (n = 3-5). Data are expressed as % injected dose per gram of tissue (mean values ± SD). The radioactivity in the urine + bladder is expressed as % injected dose per tissue

Blood

1 h

0.92 ± 0.15

0.70 ± 0.12

1.0 ± 0.16

0.93 ± 0.22

0.79 ± 0.13

0.85 ± 0.15

2 h

0.51 ± 0.07

0.60 ± 0.09

0.55 ± 0.10

0.64 ± 0.16

0.37 ± 0.10

0.30 ± 0.04

Lungs

1 h

0.55 ± 0.10

1.86 ± 0.14

2.80 ± 0.55

1.82 ± 0.30

1.05 ± 0.17

2.35 ± 0.33

2 h

0.36 ± 0.03

0.61 ± 0.07

1.15 ± 0.23

1.26 ± 0.25

0.67 ± 0.13

0.70 ± 0.16

Stomach

1 h

0.73 ± 0.13

0.87 ± 0.11

1.34 ± 0.29

1.0 ± 0.20

0.87 ± 0.19

0.83 ± 0.21

2 h

0.34 ± 0.05

0.60 ± 0.07

0.49 ± 0.12

0.52 ± 0.13

0.46 ± 0.05

0.37 ± 0.07

Spleen

1 h

0.25 ± 0.02

0.33 ± 0.02

0.22 ± 0.07

0.18 ± 0.03

0.26 ± 0.03

0.44 ± 0.06

2 h

0.14 ± 0.01

0.16 ± 0.01

0.12 ± 0.02

0.09 ± 0.02

0.17 ± 0.02

0.35 ± 0.03

Pancreas

1 h

1.65 ± 0.14

1.30 ± 0.18

2.94 ± 0.43

1.81 ± 0.22

1.05 ± 0.12

1.19 ± 0.15

2 h

0.82 ± 0.10

0.75 ± 0.11

1.18 ± 0.31

0.93 ± 0.15

0.88 ± 0.11

0.71 ± 0.10

Liver

1 h

1.02 ± 0.16

2.20 ± 0.33

2.54 ± 0.46

2.28 ± 0.31

1.40 ± 0.26

2.31 ± 0.38

2 h

0.91 ± 0.10

1.83 ± 0.24

2.0 ± 0.37

1.71 ± 0.20

1.12 ± 0.19

1.50 ± 0.27

Intestines^a

1 h

0.86 ± 0.12

0.89 ± 0.12

0.95 ± 0.27

1.01 ± 0.17

0.90 ± 0.12

1.05 ± 0.18

2 h

0.61 ± 0.06

0.50 ± 0.10

0.54 ± 0.16

0.76 ± 0.12

0.60 ± 0.10

0.73 ± 0.13

Muscle

1 h

0.23 ± 0.03

0.28 ± 0.04

0.32 ± 0.06

0.36 ± 0.07

0.30 ± 0.06

0.39 ± 0.03

2 h

0.19 ± 0.02

0.20 ± 0.02

0.26 ± 0.05

0.28 ± 0.04

0.21 ± 0.03

0.23 ± 0.02

Kidneys

1 h

4.93 ± 0.38

4.85 ± 0.43

6.03 ± 1.0

6.52 ± 0.60

5.94 ± 0.63

5.12 ± 0.69

2 h

4.01 ± 0.41

3.74 ± 0.24

5.0 ± 0.77

3.96 ± 0.48

3.20 ± 0.32

3.56 ± 0.50

Urine + bladder

1 h

64.0 ± 9.15

66.0 ± 6.60

61.0 ± 9.93

58.0 ± 6.25

62.0 ± 6.28

54.0 ± 5.78

2 h

70.0 ± 8.70

68.0 ± 7.55

78.0±5.89

65.0 ± 9.13

71.0 ± 9.68

61.0 ± 7.10

Tumor

1 h

2.32 ± 0.25

2.09 ± 0.33

1.84 ± 0.40

2.15 ± 0.33

1.82 ± 0.26

1.78 ± 0.40

2 h

1.65 ± 0.19

1.62 ± 0.18

1.30 ± 0.37

1.37 ± 0.25

0.84 ± 0.13

1.25 ± 0.21