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Table 4 In vivo biodistribution of 68Ga-labeled DOTA-BN peptides in nude mice with MDA-MB-231 tumors at 1 h and 2 h post-injection (n = 3-5). Data are expressed as % injected dose per gram of tissue (mean values ± SD). The radioactivity in the urine + bladder is expressed as % injected dose per tissue

From: A convenient and efficient total solid-phase synthesis of DOTA-functionalized tumor-targeting peptides for PET imaging of cancer

  68Ga-DOTA-Ahx-BN 68Ga-DOTA-Abz-BN 68Ga-DOTA-ALA-BN
  Time/p.i. Cyclen Tris- Cyclen Tris- Cyclen Tris-
Blood 1 h 0.92 ± 0.15 0.70 ± 0.12 1.0 ± 0.16 0.93 ± 0.22 0.79 ± 0.13 0.85 ± 0.15
2 h 0.51 ± 0.07 0.60 ± 0.09 0.55 ± 0.10 0.64 ± 0.16 0.37 ± 0.10 0.30 ± 0.04
Lungs 1 h 0.55 ± 0.10 1.86 ± 0.14 2.80 ± 0.55 1.82 ± 0.30 1.05 ± 0.17 2.35 ± 0.33
2 h 0.36 ± 0.03 0.61 ± 0.07 1.15 ± 0.23 1.26 ± 0.25 0.67 ± 0.13 0.70 ± 0.16
Stomach 1 h 0.73 ± 0.13 0.87 ± 0.11 1.34 ± 0.29 1.0 ± 0.20 0.87 ± 0.19 0.83 ± 0.21
2 h 0.34 ± 0.05 0.60 ± 0.07 0.49 ± 0.12 0.52 ± 0.13 0.46 ± 0.05 0.37 ± 0.07
Spleen 1 h 0.25 ± 0.02 0.33 ± 0.02 0.22 ± 0.07 0.18 ± 0.03 0.26 ± 0.03 0.44 ± 0.06
2 h 0.14 ± 0.01 0.16 ± 0.01 0.12 ± 0.02 0.09 ± 0.02 0.17 ± 0.02 0.35 ± 0.03
Pancreas 1 h 1.65 ± 0.14 1.30 ± 0.18 2.94 ± 0.43 1.81 ± 0.22 1.05 ± 0.12 1.19 ± 0.15
2 h 0.82 ± 0.10 0.75 ± 0.11 1.18 ± 0.31 0.93 ± 0.15 0.88 ± 0.11 0.71 ± 0.10
Liver 1 h 1.02 ± 0.16 2.20 ± 0.33 2.54 ± 0.46 2.28 ± 0.31 1.40 ± 0.26 2.31 ± 0.38
2 h 0.91 ± 0.10 1.83 ± 0.24 2.0 ± 0.37 1.71 ± 0.20 1.12 ± 0.19 1.50 ± 0.27
Intestinesa 1 h 0.86 ± 0.12 0.89 ± 0.12 0.95 ± 0.27 1.01 ± 0.17 0.90 ± 0.12 1.05 ± 0.18
2 h 0.61 ± 0.06 0.50 ± 0.10 0.54 ± 0.16 0.76 ± 0.12 0.60 ± 0.10 0.73 ± 0.13
Muscle 1 h 0.23 ± 0.03 0.28 ± 0.04 0.32 ± 0.06 0.36 ± 0.07 0.30 ± 0.06 0.39 ± 0.03
2 h 0.19 ± 0.02 0.20 ± 0.02 0.26 ± 0.05 0.28 ± 0.04 0.21 ± 0.03 0.23 ± 0.02
Kidneys 1 h 4.93 ± 0.38 4.85 ± 0.43 6.03 ± 1.0 6.52 ± 0.60 5.94 ± 0.63 5.12 ± 0.69
2 h 4.01 ± 0.41 3.74 ± 0.24 5.0 ± 0.77 3.96 ± 0.48 3.20 ± 0.32 3.56 ± 0.50
Urine + bladder 1 h 64.0 ± 9.15 66.0 ± 6.60 61.0 ± 9.93 58.0 ± 6.25 62.0 ± 6.28 54.0 ± 5.78
2 h 70.0 ± 8.70 68.0 ± 7.55 78.0±5.89 65.0 ± 9.13 71.0 ± 9.68 61.0 ± 7.10
Tumor 1 h 2.32 ± 0.25 2.09 ± 0.33 1.84 ± 0.40 2.15 ± 0.33 1.82 ± 0.26 1.78 ± 0.40
2 h 1.65 ± 0.19 1.62 ± 0.18 1.30 ± 0.37 1.37 ± 0.25 0.84 ± 0.13 1.25 ± 0.21
  1. aParts of the intestines were measured without their contents