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Table 3 In vivo biodistribution of 68Ga-DOTA-labeled BN peptides in Balb/c mice at 1 h and 2 h post-injection (n = 3-5). Data are expressed as % injected dose per gram of tissue (mean values ± SD). Urinary excretion values (% injected dose) were calculated by measuring the radioactivity associated with the excreted urine and bladder contents at the time of sacrifice at 1 and 2 h post-injection

From: A convenient and efficient total solid-phase synthesis of DOTA-functionalized tumor-targeting peptides for PET imaging of cancer

 

68Ga-DOTA-Ahx-BN

68Ga-DOTA-Abz-BN

68Ga-DOTA-ALA-BN

 

Time/p.i.

Cyclen

Tris-

Cyclen

Tris-

Cyclen

Tris-

%ID/g in:

Blood

1 h

0.18 ± 0.04

0.29 ± 0.05

0.40 ± 0.11

0.66 ± 0.13

0.80 ± 0.16

0.88 ± 0.14

2 h

0.11 ± 0.03

0.17 ± 0.02

0.12 ± 0.02

0.31 ± 0.05

0.51 ± 0.12

0.27 ± 0.02

Lungs

1 h

0.19 ± 0.04

0.36 ± 0.10

0.21 ± 0.05

0.58 ± 0.10

1.39 ± 0.30

0.42 ± 0.10

2 h

0.10 ± 0.02

0.22 ± 0.05

0.13 ± 0.03

0.40 ± 0.08

0.98 ± 0.23

0.19 ± 0.03

Stomach

1 h

1.48 ± 0.22

1.71 ± 0.19

1.69 ± 0.24

1.82 ± 0.36

1.50 ± 0.37

1.44 ± 0.26

2 h

0.43 ± 0.11

0.48 ± 0.06

0.45 ± 0.10

0.52 ± 0.12

0.44 ± 0.10

0.53 ± 0.09

Spleen

1 h

0.13 ± 0.01

0.09 ± 0.01

0.12 ± 0.02

0.11 ± 0.01

0.10 ± 0.01

0.14 ± 0.03

2 h

0.09 ± 0.01

0.06 ± 0.0

0.07 ± 0.01

0.10 ± 0.01

0.08 ± 0.0

0.10 ± 0.02

Pancreas

1 h

1.49 ± 0.12

2.0 ± 0.27

1.07 ± 0.13

1.48 ± 0.12

1.54 ± 0.31

0.98 ± 0.13

2 h

1.02 ± 0.15

1.25 ± 0.13

0.88 ± 0.11

0.97 ± 0.05

0.89 ± 0.12

0.82 ± 0.12

Liver

1 h

0.61 ± 0.10

1.12 ± 0.30

0.68 ± 0.16

1.59 ± 0.23

2.30 ± 0.37

1.78 ± 0.26

2 h

0.46 ± 0.07

0.53 ± 0.09

0.50 ± 0.07

0.91 ± 0.15

1.75 ± 0.26

0.86 ± 0.17

Intestinesa

1 h

0.64 ± 0.12

0.67 ± 0.12

0.85 ± 0.17

0.79 ± 0.16

0.88 ± 0.15

0.85 ± 0.13

2 h

0.41 ± 0.05

0.43 ± 0.09

0.53 ± 0.14

0.61 ± 0.09

0.73 ± 0.12

0.64 ± 0.14

Bone

1 h

0.15 ± 0.03

0.17 ± 0.03

0.13 ± 0.04

0.22 ± 0.05

0.24 ± 0.04

0.14 ± 0.03

2 h

0.06 ± 0.0

0.09 ± 0.01

0.09 ± 0.01

0.12 ± 0.01

0.15 ± 0.02

0.08 ± 0.01

Kidneys

1 h

1.98 ± 0.34

2.89 ± 0.41

2.96±0.30

4.0 ± 0.82

5.89 ± 1.0

3.83 ± 0.67

2 h

1.41 ± 0.27

1.63 ± 0.24

1.88 ± 0.25

2.86 ± 0.37

3.05 ± 0.41

2.76 ± 0.49

%ID excreted in:

Urine

1 h

80.0 ± 9.80

74.0 ± 8.03

70.0 ± 8.60

43.0 ± 8.70

53.0 ± 6.80

71.0 ± 12.45

2 h

64.0 ± 6.35

69.0 ± 5.15

62.0 ± 9.54

50.0 ± 3.45

46.0 ± 9.12

78.0 ± 15.0

Feces

1 h

0.85 ± 0.17

0.83 ± 0.19

1.01 ± 0.20

0.90 ± 0.10

1.07 ± 0.17

1.03 ± 0.12

2 h

0.76 ± 0.11

0.69 ± 0.10

0.88 ± 0.12

0.59 ± 0.08

0.91 ± 0.14

0.77 ± 0.10

  1. aParts of the intestines were measured without their contents