| 68Ga-DOTA-Ahx-BN | 68Ga-DOTA-Abz-BN | 68Ga-DOTA-ALA-BN | ||||
---|---|---|---|---|---|---|---|
 | Time/p.i. | Cyclen | Tris- | Cyclen | Tris- | Cyclen | Tris- |
%ID/g in: | |||||||
Blood | 1 h | 0.18 ± 0.04 | 0.29 ± 0.05 | 0.40 ± 0.11 | 0.66 ± 0.13 | 0.80 ± 0.16 | 0.88 ± 0.14 |
2 h | 0.11 ± 0.03 | 0.17 ± 0.02 | 0.12 ± 0.02 | 0.31 ± 0.05 | 0.51 ± 0.12 | 0.27 ± 0.02 | |
Lungs | 1 h | 0.19 ± 0.04 | 0.36 ± 0.10 | 0.21 ± 0.05 | 0.58 ± 0.10 | 1.39 ± 0.30 | 0.42 ± 0.10 |
2 h | 0.10 ± 0.02 | 0.22 ± 0.05 | 0.13 ± 0.03 | 0.40 ± 0.08 | 0.98 ± 0.23 | 0.19 ± 0.03 | |
Stomach | 1 h | 1.48 ± 0.22 | 1.71 ± 0.19 | 1.69 ± 0.24 | 1.82 ± 0.36 | 1.50 ± 0.37 | 1.44 ± 0.26 |
2 h | 0.43 ± 0.11 | 0.48 ± 0.06 | 0.45 ± 0.10 | 0.52 ± 0.12 | 0.44 ± 0.10 | 0.53 ± 0.09 | |
Spleen | 1 h | 0.13 ± 0.01 | 0.09 ± 0.01 | 0.12 ± 0.02 | 0.11 ± 0.01 | 0.10 ± 0.01 | 0.14 ± 0.03 |
2 h | 0.09 ± 0.01 | 0.06 ± 0.0 | 0.07 ± 0.01 | 0.10 ± 0.01 | 0.08 ± 0.0 | 0.10 ± 0.02 | |
Pancreas | 1 h | 1.49 ± 0.12 | 2.0 ± 0.27 | 1.07 ± 0.13 | 1.48 ± 0.12 | 1.54 ± 0.31 | 0.98 ± 0.13 |
2 h | 1.02 ± 0.15 | 1.25 ± 0.13 | 0.88 ± 0.11 | 0.97 ± 0.05 | 0.89 ± 0.12 | 0.82 ± 0.12 | |
Liver | 1 h | 0.61 ± 0.10 | 1.12 ± 0.30 | 0.68 ± 0.16 | 1.59 ± 0.23 | 2.30 ± 0.37 | 1.78 ± 0.26 |
2 h | 0.46 ± 0.07 | 0.53 ± 0.09 | 0.50 ± 0.07 | 0.91 ± 0.15 | 1.75 ± 0.26 | 0.86 ± 0.17 | |
Intestinesa | 1 h | 0.64 ± 0.12 | 0.67 ± 0.12 | 0.85 ± 0.17 | 0.79 ± 0.16 | 0.88 ± 0.15 | 0.85 ± 0.13 |
2 h | 0.41 ± 0.05 | 0.43 ± 0.09 | 0.53 ± 0.14 | 0.61 ± 0.09 | 0.73 ± 0.12 | 0.64 ± 0.14 | |
Bone | 1 h | 0.15 ± 0.03 | 0.17 ± 0.03 | 0.13 ± 0.04 | 0.22 ± 0.05 | 0.24 ± 0.04 | 0.14 ± 0.03 |
2 h | 0.06 ± 0.0 | 0.09 ± 0.01 | 0.09 ± 0.01 | 0.12 ± 0.01 | 0.15 ± 0.02 | 0.08 ± 0.01 | |
Kidneys | 1 h | 1.98 ± 0.34 | 2.89 ± 0.41 | 2.96±0.30 | 4.0 ± 0.82 | 5.89 ± 1.0 | 3.83 ± 0.67 |
2 h | 1.41 ± 0.27 | 1.63 ± 0.24 | 1.88 ± 0.25 | 2.86 ± 0.37 | 3.05 ± 0.41 | 2.76 ± 0.49 | |
%ID excreted in: | |||||||
Urine | 1 h | 80.0 ± 9.80 | 74.0 ± 8.03 | 70.0 ± 8.60 | 43.0 ± 8.70 | 53.0 ± 6.80 | 71.0 ± 12.45 |
2 h | 64.0 ± 6.35 | 69.0 ± 5.15 | 62.0 ± 9.54 | 50.0 ± 3.45 | 46.0 ± 9.12 | 78.0 ± 15.0 | |
Feces | 1 h | 0.85 ± 0.17 | 0.83 ± 0.19 | 1.01 ± 0.20 | 0.90 ± 0.10 | 1.07 ± 0.17 | 1.03 ± 0.12 |
2 h | 0.76 ± 0.11 | 0.69 ± 0.10 | 0.88 ± 0.12 | 0.59 ± 0.08 | 0.91 ± 0.14 | 0.77 ± 0.10 |