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Table 3 In vivo biodistribution of 68Ga-DOTA-labeled BN peptides in Balb/c mice at 1 h and 2 h post-injection (n = 3-5). Data are expressed as % injected dose per gram of tissue (mean values ± SD). Urinary excretion values (% injected dose) were calculated by measuring the radioactivity associated with the excreted urine and bladder contents at the time of sacrifice at 1 and 2 h post-injection

From: A convenient and efficient total solid-phase synthesis of DOTA-functionalized tumor-targeting peptides for PET imaging of cancer

  68Ga-DOTA-Ahx-BN 68Ga-DOTA-Abz-BN 68Ga-DOTA-ALA-BN
  Time/p.i. Cyclen Tris- Cyclen Tris- Cyclen Tris-
%ID/g in:
Blood 1 h 0.18 ± 0.04 0.29 ± 0.05 0.40 ± 0.11 0.66 ± 0.13 0.80 ± 0.16 0.88 ± 0.14
2 h 0.11 ± 0.03 0.17 ± 0.02 0.12 ± 0.02 0.31 ± 0.05 0.51 ± 0.12 0.27 ± 0.02
Lungs 1 h 0.19 ± 0.04 0.36 ± 0.10 0.21 ± 0.05 0.58 ± 0.10 1.39 ± 0.30 0.42 ± 0.10
2 h 0.10 ± 0.02 0.22 ± 0.05 0.13 ± 0.03 0.40 ± 0.08 0.98 ± 0.23 0.19 ± 0.03
Stomach 1 h 1.48 ± 0.22 1.71 ± 0.19 1.69 ± 0.24 1.82 ± 0.36 1.50 ± 0.37 1.44 ± 0.26
2 h 0.43 ± 0.11 0.48 ± 0.06 0.45 ± 0.10 0.52 ± 0.12 0.44 ± 0.10 0.53 ± 0.09
Spleen 1 h 0.13 ± 0.01 0.09 ± 0.01 0.12 ± 0.02 0.11 ± 0.01 0.10 ± 0.01 0.14 ± 0.03
2 h 0.09 ± 0.01 0.06 ± 0.0 0.07 ± 0.01 0.10 ± 0.01 0.08 ± 0.0 0.10 ± 0.02
Pancreas 1 h 1.49 ± 0.12 2.0 ± 0.27 1.07 ± 0.13 1.48 ± 0.12 1.54 ± 0.31 0.98 ± 0.13
2 h 1.02 ± 0.15 1.25 ± 0.13 0.88 ± 0.11 0.97 ± 0.05 0.89 ± 0.12 0.82 ± 0.12
Liver 1 h 0.61 ± 0.10 1.12 ± 0.30 0.68 ± 0.16 1.59 ± 0.23 2.30 ± 0.37 1.78 ± 0.26
2 h 0.46 ± 0.07 0.53 ± 0.09 0.50 ± 0.07 0.91 ± 0.15 1.75 ± 0.26 0.86 ± 0.17
Intestinesa 1 h 0.64 ± 0.12 0.67 ± 0.12 0.85 ± 0.17 0.79 ± 0.16 0.88 ± 0.15 0.85 ± 0.13
2 h 0.41 ± 0.05 0.43 ± 0.09 0.53 ± 0.14 0.61 ± 0.09 0.73 ± 0.12 0.64 ± 0.14
Bone 1 h 0.15 ± 0.03 0.17 ± 0.03 0.13 ± 0.04 0.22 ± 0.05 0.24 ± 0.04 0.14 ± 0.03
2 h 0.06 ± 0.0 0.09 ± 0.01 0.09 ± 0.01 0.12 ± 0.01 0.15 ± 0.02 0.08 ± 0.01
Kidneys 1 h 1.98 ± 0.34 2.89 ± 0.41 2.96±0.30 4.0 ± 0.82 5.89 ± 1.0 3.83 ± 0.67
2 h 1.41 ± 0.27 1.63 ± 0.24 1.88 ± 0.25 2.86 ± 0.37 3.05 ± 0.41 2.76 ± 0.49
%ID excreted in:
Urine 1 h 80.0 ± 9.80 74.0 ± 8.03 70.0 ± 8.60 43.0 ± 8.70 53.0 ± 6.80 71.0 ± 12.45
2 h 64.0 ± 6.35 69.0 ± 5.15 62.0 ± 9.54 50.0 ± 3.45 46.0 ± 9.12 78.0 ± 15.0
Feces 1 h 0.85 ± 0.17 0.83 ± 0.19 1.01 ± 0.20 0.90 ± 0.10 1.07 ± 0.17 1.03 ± 0.12
2 h 0.76 ± 0.11 0.69 ± 0.10 0.88 ± 0.12 0.59 ± 0.08 0.91 ± 0.14 0.77 ± 0.10
  1. aParts of the intestines were measured without their contents