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Fig. 4 | EJNMMI Research

Fig. 4

From: A convenient and efficient total solid-phase synthesis of DOTA-functionalized tumor-targeting peptides for PET imaging of cancer

Fig. 4

An example of the mass spectrum profile of the DOTA-Ahx-BN prepared from cyclen procedure (above) and with DOTA-tris (t-Bu ester) (below). It can be seen that no overalkylating product was observed when the DOTA-Ahx-BN synthesized by the cyclen approach. While tetraalkylating product 1813 (M + t-Bu + H)+ is clearly visible in the spectrum when the DOTA-peptide was prepared using DOTA-tris (t-Bu ester)

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