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Table 3 Planned and delivered dose results based on normalized 99mTc-MAA SPECT and 90Y-microsphere PET respectively

From: Analysis of differences between 99mTc-MAA SPECT- and 90Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy

 

Normalized 99mTc-MAA SPECT

Mean ± SD

90Y-MS PET

Mean ± SD

Bias [95% CI]

Pearson’s correlation

DT (Gy)

169 ± 40

165 ± 47

4 [−5; 13]

0.87 (P = 3.10−8)

D20 (Gy)

250 ± 67

251 ± 78

− 1 [− 15; 14]

0.89 (P = 7.10−9)

D50 (Gy)

156 ± 44

144 ± 51

12 [0; 25]

0.79 (P = 4.10−6)

D70 (Gy)

104 ± 36

91 ± 38

13 [1; 25]*

0.67 (P = 3.10−4)

V205 (%)

30 ± 18

30 ± 16

0 [− 3; 4]

0.85 (P = 1.10−7)

DNL (Gy)

36 ± 16

34 ± 15

1 [− 1; 4]

0.91 (P = 6.10−10)

  1. MS microsphere, MAA macroaggregated albumin, SD standard deviation, DT mean dose to the tumor, D20 minimum dose to 20% of the tumor volume, D50 minimum dose to 50% of the tumor volume, D70 minimum dose to 70% of the tumor volume, V205 percentage of the volume receiving more than 205 Gy, DNL mean dose to the normal liver. Bias and correlation are with respect to 90Y-MS PET
  2. *P ≤ 0.05