Table 1 Organ and tumor masses used for dosimetry calculations. Mean organ and tumor masses obtained by direct harvesting and weighing, as well as those obtained by PET/CT imaging segmentation, are shown together with the standard organ masses implemented in the mouse model 25 g of OLINDA2. The standard organ masses of OLINDA2 were used for dose estimations in the organs that were not harvested or segmented in the biodistribution and microPET experiments, respectively (indicated with –)
From: Internal radiation dosimetry of a 152Tb-labeled antibody in tumor-bearing mice
Source organ | Average organ masses (g) | ||
|---|---|---|---|
Biodistribution | MicroPET/CT | OLINDA2 | |
Brain | – | – | 0.46 |
LLI contents | 0.76 (± 0.18) | 1.19 (± 0.53) | 0.58 |
Small intestine | 1.26 (± 0.24) | 3.56 (± 1.61) | 1.74 |
Stomach | 0.59 (± 0.20) | – | 0.05 |
Heart wall | 0.10 (± 0.01) | 0.19 (± 0.08) | 0.23 |
Kidneys | 0.26 (± 0.03) | 0.21 (± 0.11) | 0.30 |
Liver | 0.97 (± 0.15) | 1.18 (± 0.26) | 1.73 |
Lungs | 0.17 (± 0.03) | 0.24 (± 0.04) | 0.08 |
Pancreas | 0.10 (± 0.02) | – | 0.30 |
Cortical bone | – | – | 2.18 |
Spleen | 0.04 (± 0.03) | – | 0.11 |
Testes | – | – | 0.16 |
Thyroid | – | – | 0.01 |
Urinary bladder contents | – | – | 0.06 |
Tumor | 1.05 (± 0.35) | 0.79 (± 0.20) | N.A. |
Uterus and ovary | 0.25 (± 0.07) | – | N.A.† |