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Scheme 1 | EJNMMI Research

Scheme 1

From: Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

Scheme 1

Radiosynthesis of [44Sc]3. The DOTA-functionalized Tz (1) was added to a solution of 44ScCl3 in ammonium acetate (pH 4) and ethanol. The solution was heated to 95 °C for 10 min. After cooling to room temperature, the solution was loaded on to an SPE column, flushed with water, and the pure product eluted with ethanol. [44Sc]3 was obtained in 85–95% RCY and > 99% RCP.

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