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Fig. 5 | EJNMMI Research

Fig. 5

From: Correlation between 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer

Fig. 5

A representative case of a 66-year-old patient with preoperative PSA of 4.6 ng/ml. HE staining of the whole mount prostatectomy section indicates a solitary lesion in the right peripheral lobe (a). Axial PET/CT shows conspicuous high 18F-fluciclovine uptake (SUVmax at 22 min = 9.5) in the tumor (b). Low (× 10, scale bar 200 μm) and high magnification (× 20, scale bar 100 μm) images of HE-stained TMA core from the tumor show Gleason 4 + 5 adenocarcinoma (c, d). Parallel sections used for immunohistochemistry show high ASCT2 (e, f) and moderate LAT1 (g, h) staining intensity

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