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EJNMMI Research

Table 2 Pharmacokinetic parameters for nano-carrier 188Re-liposome uptake after intravenous injection for patients (n = 12) with tumors

From: A phase 0 study of the pharmacokinetics, biodistribution, and dosimetry of 188Re-liposome in patients with metastatic tumors

Parameters

Blood

Plasma

Cmax (%ID/mL)

0.01 ± 0.01

0.02 ± 0.02

Cl (mL/h)

749.40 ± 663.19

494.26 ± 447.01

AUC0→∞(%ID /mL*h)

0.33 ± 0.32

0.50 ± 0.46

T1/2Z (h)

36.73 ± 14.00

52.02 ± 45.21

  1. Pharmacokinetic parameters are determined using WinNonlin software version 5.3 (Pharsight Corp., Mountain View, CA, USA)
  2. Cmax maximum concentration, Cl clearance rate, AUC area under curve, T1/2Z elimination half-life
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