Fig. 2

Representative [¹⁸F]FMISO PET/CT images (a, b, c) and HIF-1α immunohistochemical images (d, e) of pancreatic cancer. A color bar from 0 to 3 indicates standardize uptake value (SUV) of fused [¹⁸F]FMISO images. The first case with increased [¹⁸F]FMISO uptake on the primary tumor (a, arrows) was finally decided as inoperable. The second case with moderate [¹⁸F]FMISO uptake (b, arrows) received operation, and the immunohistochemistry shows strong HIF-1α expression (d). The third case with low [¹⁸F]FMISO uptake (c, arrows) also received operation, and the immunohistochemistry shows no apparent HIF-1α expression (e)