Skip to main content

Advertisement

Table 1 Area (AUC) under the ROC curve, cut-off (based on Youden’s criterion), and resulting total accuracy, sensitivity, and specificity for identification of neurodegenerative etiology of parkinsonism (mono-site/mono-camera setting) or PD (multi-site/multi-camera setting). (Cau = caudate, Put = putamen, Str = striatum, ant = anterior, post = posterior)

From: Diagnostic performance of the specific uptake size index for semi-quantitative analysis of I-123-FP-CIT SPECT: harmonized multi-center research setting versus typical clinical single-camera setting

  SBR SUSI in MNI space SUSI in patient space
Cau Put ant Put post Put Str Cau Put Str Cau Put Str
Mono-camera AUC (95% CI) 0.636bbb,ccc (0.526–0.746) 0.976c (0.954–0.999) 0.935b (0.891–0.980) 0.981c (0.960–1.000) 0.925 (0.877–0.973) 0.764aaa (0.673–0.855) 0.969 (0.943–0.996) 0.927 (0.881–0.974) 0.765aaa (0.675–0.855) 0.961a (0.930–0.993) 0.924 (0.874–0.974)
Cut-off 1.829 2.383 1.866 1.776 2.051 16.418 16.974 34.902 12.913 8.371 23.653
Accuracy 0.672 0.943 0.885 0.943 0.877 0.705 0.934 0.877 0.770 0.902 0.877
Sensitivity 0.762 0.940 0.857 0.917 0.881 0.643 0.929 0.869 0.821 0.881 0.881
Specificity 0.474 0.947 0.947 1.000 0.868 0.842 0.947 0.895 0.658 0.947 0.868
Multi-camera AUC (95% CI) 0.884bbb (0.856–0.911) 0.991 (0.987–0.996) 0.966bbb (0.954–0.978) 0.998b (0.996–1.000) 0.979 (0.971–0.988) 0.920aaa (0.898–0.942) 0.993 (0.989–0.998) 0.978 (0.969–0.987)
Cut-off 1.781 2.068 1.776 1.597 1.960 21.229 14.799 39.171
Accuracy 0.780 0.953 0.898 0.980 0.930 0.839 0.964 0.933
Sensitivity 0.719 0.943 0.872 0.973 0.916 0.822 0.961 0.945
Specificity 0.908 0.976 0.952 0.995 0.961 0.874 0.971 0.908
  1. Statistical testing was restricted to caudate versus caudate, putamen versus putamen, and striatum versus striatum
  2. a/aa/aaaDeLong test p < 0.05/0.01/0.005 compared to SBR
  3. b/bb/bbbDeLong test p < 0.05/0.01/0.005 compared to SUSI in MNI space
  4. c/cc/cccDeLong test p < 0.05/0.01/0.005 compared to SUSI in patient space