Skip to main content
EJNMMI Research

Table 3 Predicted upstream regulators affected in GOT1 tumors after 177Lu-octreotate therapy with priming

From: Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice

 

Upstream regulator

z

p

Targets from transcriptional data

1 day

 

GDF15

–

6.1 × 10−6

↑CDKN1A, ↑GDF15

 

PPP5C

–

1.8 × 10−5

↑CDKN1A, ↑SGK

 

SATB1

0.11

7.8 × 10−5

↑CDKN1A, ↑F5, ↑FAM129A, ↑SGK

 

RNF2

–

1.3 × 10−4

↑CDKN1A, ↑GDF15

 

FH

–

2.2 × 10−4

↑APOD, ↑CDKN1A

3 days

►

p53

3.3

6.0 × 10−14

↑ACTA2, ↑APOE, ↑BAX, ↑CCND3, ↑CDKN1A, ↓CTGF, ↑DDB2, ↑DDIT3, ↓FDFT1, ↑GADD45A, ↑GDF15, ↑NINJ1, ↓PBK, ↑PHLDA3, ↑SPATA18, ↑TIGAR, ↑TNFRSF10B, ↑VCAN

►

ANXA2

−2.0

8.1 × 10−9

↑BAX, ↑CDKN1A, ↑GADD45A, ↑TNFRSF10B, ↑ZMAT3

 

MYC

−0.32

2.0 × 10−8

↑BAX, ↑CCND3, ↑CDKN1A, ↑DDB2, ↑DDIT3, ↓EXOSC8, ↑GADD45A, ↑HSPH1, ↑TNFRSF10B

 

PPARGC1A

0.32

8.3 × 10−8

↑BAX, ↑CDKN1A, ↓INSIG1, ↓LDLR, ↑TIGAR

►

KDM5B

2.6

2.0 × 10−5

↑DDIT3, ↓DLGAP5, ↑GADD45A, ↓INSIG1, ↓PBK

7 days

 

PPARG

0.17

9.8 × 10−8

↑ACTA2, ↑CDH1, ↑CDKN1A, ↑CTSL, ↓INSIG1, ↓PDK4

►

PARP1

−2.0

3.7 × 10−7

↑CDH1, ↓PEG10, ↓TMSB15A, ↑TNFRSF10B

 

p53

1.9

1.0 × 10−6

↑ACTA2, ↑APOE, ↑CDH1, ↑CDKN1A, ↑F5, ↓FDFT1, ↑GDF15, ↑NINJ1, ↓PEG10, ↑PHLDA3, ↓TMSB15A, ↑TNFRSF10B

 

SKI

–

1.1 × 10−6

↑ACTA2, ↑CDH1, ↑CDKN1A

 

GDF15

–

1.5 × 10−5

↑CDKN1A, ↑GDF15

41 days

►

LIN28B

–

4.5 × 10−5

↓BCL11A, ↓SOX2

 

ID1

–

1.9 × 10−4

↓EGR1, ↓SOX2

►

CDX2

–

1.1 × 10−3

↓NR2F2, ↓SOX2

 

SHP

–

1.3 × 10−3

↓EGR1

 

mir-140

–

1.3 × 10−3

↓SOX2

  1. Significantly affected upstream regulators identified with IPA (Fisher’s exact test, p < 0.05), ranked according to the lowest p value, for each time point. z scores indicate activation state of the upstream regulator; z > 2 indicates activation, and z < −2 indicates inhibition. Up and down arrows indicate upregulated and downregulated genes in tumor samples from treated animals compared with controls, respectively. ► indicates the upstream regulator was not affected in animals treated with 15 MBq single administration of 177Lu-octreotate (from GEO accession GSE80024)
Back to article page