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Fig. 2 | EJNMMI Research

Fig. 2

From: Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice

Fig. 2

Distribution of significantly regulated genes after 177Lu-octreotate therapy with priming. Expression profiles of the 187 significantly regulated transcripts after i.v. injection of 5 + 10 MBq 177Lu-octreotate at 1, 3, 7, or 41 days after the last injection and annotation of enriched GO terms. Unsupervised hierarchical clustering was performed based on expression profiles. The mean absorbed dose to tumors processed for transcriptional analysis is indicated by the corresponding time point. Red and green indicate up- and downregulated transcripts (treated versus control, fold change ≥ 1.5, FDR-adjusted p < 0.01), respectively. In the lower segment, orange and blue indicate significant annotation (modified Fisher’s exact test, p < 0.05) of a gene to a GO term in a specified category. Orange indicates the GO annotation was significant both in animals treated with 5 + 10 MBq and in animals treated with 15 MBq single administration of 177Lu-octreotate (from GEO accession GSE80024), while blue indicates a significant GO annotation only in animals receiving 5 + 10 MBq 177Lu-octreotate

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