Optimized dual-time-window protocols for quantitative [18F]flutemetamol and [18F]florbetaben PET studies

Heeman, Fiona; Yaqub, Maqsood; Lopes Alves, Isadora; Heurling, Kerstin; Berkhof, Johannes; Gispert, Juan Domingo; Bullich, Santiago; Foley, Christopher; Lammertsma, Adriaan A.

doi:10.1186/s13550-019-0499-4

EJNMMI Research

Table 6 Absolute bias in BP_ND and AUC as a result of noise and the dual-time-window protocol for SRTM-generated [¹⁸F]florbetaben TACs

From: Optimized dual-time-window protocols for quantitative [¹⁸F]flutemetamol and [¹⁸F]florbetaben PET studies

FBB		Absolute mean bias BP_ND (SD)				AUC
	Interval	0%	1%	2%	5%	0%	1%	2%	5%
BP_ND I	10–90	0.000 (0.000)	0.012 (0.026)	0.021 (0.043)	0.059 (0.080)	0.993	0.979	0.966	0.929
	20–90	0.000 (0.000)	0.000 (0.011)	0.013 (0.040)	0.048 (0.076)	0.993	0.986	0.971	0.937
	30–90	0.000 (0.000)	0.000 (0.008)	0.001 (0.028)	0.006 (0.046)	0.993	0.988	0.979	0.968
	40–90	0.000 (0.000)	0.003 (0.032)	0.008 (0.014)	0.021 (0.063)	0.993	0.978	0.981	0.956
	50–90	0.000 (0.000)	0.009 (0.012)	0.000 (0.037)	0.012 (0.056)	0.993	0.983	0.978	0.962
	60–90	0.000 (0.000)	0.000 (0.007)	0.001 (0.015)	0.029 (0.063)	0.993	0.989	0.983	0.956
	70–90	0.000 (0.000)	0.001 (0.006)	0.000 (0.013)	0.032 (0.069)	0.993	0.990	0.984	0.953
	80–90	0.000 (0.000)	0.005 (0.036)	0.007 (0.066)	0.029 (0.081)	1.000	0.978	0.963	0.948
	90–90	0.000 (0.000)	0.010 (0.011)	0.011 (0.064)	0.024 (0.067)	1.000	0.983	0.962	0.956
BP_ND II	10–90	0.001 (0.000)	0.003 (0.013)	0.045 (0.167)	0.131 (0.307)	0.993	0.984	0.935	0.861
	20–90	0.001 (0.000)	0.000 (0.012)	0.000 (0.023)	0.079 (0.207)	0.993	0.985	0.976	0.891
	30–90	0.002 (0.000)	0.000 (0.012)	0.003 (0.023)	0.016 (0.063)	0.993	0.985	0.975	0.946
	40–90	0.000 (0.000)	0.001 (0.012)	0.001 (0.023)	0.012 (0.062)	0.993	0.985	0.976	0.946
	50–90	0.000 (0.000)	0.001 (0.011)	0.001 (0.022)	0.010 (0.060)	0.993	0.986	0.977	0.948
	60–90	0.000 (0.000)	0.002 (0.010)	0.000 (0.021)	0.009 (0.056)	0.993	0.987	0.978	0.948
	70–90	0.000 (0.000)	0.001 (0.009)	0.001 (0.020)	0.010 (0.055)	0.993	0.988	0.979	0.950
	80–90	0.000 (0.000)	0.001 (0.007)	0.002 (0.017)	0.011 (0.053)	1.000	0.989	0.981	0.954
	90–90	0.000 (0.000)	0.001 (0.008)	0.002 (0.015)	0.014 (0.053)	1.000	0.989	0.983	0.954
BP_ND III	10–90	0.002 (0.000)	0.002 (0.022)	0.014 (0.066)	0.084 (0.159)	0.993	0.978	0.955	0.875
	20–90	0.002 (0.000)	0.003 (0.016)	0.000 (0.041)	0.058 (0.117)	0.993	0.982	0.964	0.898
	30–90	0.003 (0.000)	0.004 (0.016)	0.004 (0.035)	0.038 (0.112)	0.993	0.982	0.966	0.910
	40–90	0.001 (0.000)	0.002 (0.016)	0.003 (0.036)	0.041 (0.116)	0.993	0.982	0.966	0.909
	50–90	0.001 (0.000)	0.002 (0.016)	0.002 (0.035)	0.041 (0.117)	0.993	0.982	0.967	0.908
	60–90	0.001 (0.000)	0.001 (0.015)	0.002 (0.034)	0.041 (0.114)	0.993	0.983	0.968	0.909
	70–90	0.001 (0.000)	0.001 (0.014)	0.001 (0.031)	0.037 (0.108)	0.993	0.984	0.971	0.911
	80–90	0.000 (0.000)	0.000 (0.014)	0.002 (0.030)	0.033 (0.092)	1.000	0.985	0.972	0.926
	90–90	0.000 (0.000)	0.000 (0.013)	0.003 (0.027)	0.029 (0.083)	1.000	0.985	0.974	0.933
BP_ND IV	10–90	0.003 (0.000)	0.014 (0.035)	0.014 (0.074)	0.085 (0.184)	0.993	0.964	0.943	0.848
	20–90	0.004 (0.000)	0.004 (0.024)	0.003 (0.047)	0.036 (0.148)	0.993	0.975	0.956	0.891
	30–90	0.005 (0.000)	0.001 (0.023)	0.006 (0.046)	0.011 (0.115)	0.993	0.976	0.958	0.904
	40–90	0.001 (0.000)	0.004 (0.023)	0.003 (0.046)	0.008 (0.108)	0.993	0.976	0.958	0.907
	50–90	0.001 (0.000)	0.004 (0.024)	0.002 (0.045)	0.006 (0.107)	0.993	0.975	0.959	0.909
	60–90	0.001 (0.000)	0.005 (0.022)	0.002 (0.043)	0.007 (0.099)	0.993	0.976	0.961	0.917
	70–90	0.001 (0.000)	0.004 (0.022)	0.003 (0.040)	0.006 (0.092)	0.993	0.977	0.964	0.924
	80–90	0.000 (0.000)	0.005 (0.021)	0.000 (0.037)	0.003 (0.089)	1.000	0.977	0.966	0.926
	90–90	0.000 (0.000)	0.005 (0.019)	0.000 (0.034)	0.012 (0.091)	1.000	0.978	0.970	0.925
BP_ND V	10–90	0.005 (0.000)	0.005 (0.044)	0.024 (0.122)	0.029 (0.111)	0.993	0.960	0.911	0.903
	20–90	0.006 (0.000)	0.008 (0.027)	0.015 (0.056)	0.008 (0.147)	0.988	0.971	0.950	0.882
	30–90	0.007 (0.000)	0.008 (0.027)	0.021 (0.051)	0.011 (0.165)	0.988	0.972	0.954	0.870
	40–90	0.002 (0.000)	0.002 (0.026)	0.016 (0.052)	0.018 (0.172)	0.993	0.973	0.955	0.868
	50–90	0.002 (0.000)	0.002 (0.026)	0.016 (0.052)	0.010 (0.156)	0.993	0.973	0.955	0.878
	60–90	0.001 (0.000)	0.002 (0.025)	0.016 (0.051)	0.015 (0.156)	0.993	0.974	0.955	0.875
	70–90	0.001 (0.000)	0.002 (0.024)	0.012 (0.050)	0.022 (0.153)	0.993	0.976	0.955	0.876
	80–90	0.000 (0.000)	0.002 (0.022)	0.008 (0.045)	0.027 (0.147)	0.993	0.978	0.959	0.876
	90–90	0.000 (0.000)	0.002 (0.020)	0.005 (0.041)	0.026 (0.135)	0.993	0.979	0.963	0.888

Absolute bias in \( {\mathrm{BP}}_{\mathrm{ND}}^{\mathrm{sim}} \) and the area under the curve (AUC) for the acceptability curves across all noise levels (0–5%) for [¹⁸F]florbetaben

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