Table 5 Absolute bias in BPND and AUC as a result of noise and the dual-time-window protocol for SRTM-generated [18F]flutemetamol TACs
FLUT | Absolute mean bias BPND (SD) | AUC | |||||||
|---|---|---|---|---|---|---|---|---|---|
Interval | 0% | 1% | 2% | 5% | 0% | 1% | 2% | 5% | |
BPND I | 10–90 | 0.001 (0.000) | 0.017 (0.058) | 0.042 (0.079) | 0.093 (0.154) | 0.993 | 0.971 | 0.943 | 0.894 |
20–90 | 0.001 (0.000) | 0.084 (0.283) | 0.086 (0.276) | 0.098 (0.211) | 0.993 | 0.908 | 0.902 | 0.887 | |
30–90 | 0.001 (0.000) | 0.012 (0.079) | 0.017 (0.074) | 0.105 (0.222) | 0.993 | 0.969 | 0.961 | 0.878 | |
40–90 | 0.001 (0.000) | 0.002 (0.011) | 0.006 (0.022) | 0.055 (0.113) | 0.993 | 0.986 | 0.977 | 0.929 | |
50–90 | 0.000 (0.000) | 0.002 (0.011) | 0.007 (0.025) | 0.053 (0.116) | 0.993 | 0.986 | 0.976 | 0.929 | |
60–90 | 0.000 (0.000) | 0.002 (0.029) | 0.006 (0.045) | 0.051 (0.115) | 0.993 | 0.981 | 0.974 | 0.932 | |
70–90 | 0.000 (0.000) | 0.036 (0.119) | 0.000 (0.020) | 0.075 (0.147) | 0.993 | 0.948 | 0.978 | 0.909 | |
80–90 | 0.000 (0.000) | 0.026 (0.174) | 0.035 (0.181) | 0.058 (0.133) | 1.000 | 0.955 | 0.946 | 0.923 | |
90–90 | 0.000 (0.000) | 0.018 (0.162) | 0.022 (0.162) | 0.072 (0.202) | 1.000 | 0.962 | 0.958 | 0.910 | |
BPND II | 10–90 | 0.002 (0.000) | 0.014 (0.046) | 0.081 (0.217) | 0.128 (0.271) | 0.993 | 0.970 | 0.895 | 0.838 |
20–90 | 0.001 (0.000) | 0.021 (0.135) | 0.009 (0.040) | 0.076 (0.200) | 0.993 | 0.963 | 0.965 | 0.881 | |
30–90 | 0.001 (0.000) | 0.002 (0.015) | 0.003 (0.030) | 0.043 (0.159) | 0.993 | 0.982 | 0.971 | 0.906 | |
40–90 | 0.000 (0.000) | 0.002 (0.015) | 0.003 (0.029) | 0.029 (0.112) | 0.993 | 0.982 | 0.971 | 0.919 | |
50–90 | 0.000 (0.000) | 0.002 (0.015) | 0.002 (0.029) | 0.022 (0.097) | 0.993 | 0.982 | 0.972 | 0.923 | |
60–90 | 0.000 (0.000) | 0.003 (0.014) | 0.004 (0.029) | 0.020 (0.095) | 0.993 | 0.983 | 0.972 | 0.922 | |
70–90 | 0.000 (0.000) | 0.002 (0.014) | 0.005 (0.029) | 0.020 (0.096) | 0.993 | 0.984 | 0.972 | 0.924 | |
80–90 | 0.000 (0.000) | 0.002 (0.013) | 0.007 (0.027) | 0.023 (0.098) | 1.000 | 0.985 | 0.973 | 0.924 | |
90–90 | 0.000 (0.000) | 0.003 (0.013) | 0.006 (0.024) | 0.027 (0.098) | 1.000 | 0.985 | 0.975 | 0.925 | |
BPND III | 10–90 | 0.003 (0.000) | 0.014 (0.063) | 0.031 (0.099) | 0.023 (0.128) | 0.993 | 0.956 | 0.924 | 0.898 |
20–90 | 0.002 (0.000) | 0.001 (0.026) | 0.019 (0.080) | 0.060 (0.145) | 0.993 | 0.975 | 0.946 | 0.876 | |
30–90 | 0.001 (0.000) | 0.001 (0.023) | 0.007 (0.054) | 0.056 (0.158) | 0.993 | 0.977 | 0.956 | 0.881 | |
40–90 | 0.001 (0.000) | 0.001 (0.023) | 0.004 (0.049) | 0.051 (0.146) | 0.993 | 0.978 | 0.958 | 0.885 | |
50–90 | 0.001 (0.000) | 0.001 (0.023) | 0.005 (0.048) | 0.049 (0.147) | 0.993 | 0.978 | 0.959 | 0.886 | |
60–90 | 0.001 (0.000) | 0.001 (0.022) | 0.005 (0.048) | 0.050 (0.147) | 0.993 | 0.978 | 0.959 | 0.887 | |
70–90 | 0.001 (0.000) | 0.000 (0.021) | 0.006 (0.047) | 0.047 (0.144) | 0.993 | 0.979 | 0.960 | 0.888 | |
80–90 | 0.000 (0.000) | 0.001 (0.022) | 0.010 (0.046) | 0.059 (0.164) | 1.000 | 0.979 | 0.961 | 0.883 | |
90–90 | 0.000 (0.000) | 0.001 (0.021) | 0.012 (0.043) | 0.051 (0.142) | 1.000 | 0.979 | 0.963 | 0.894 | |
BPND IV | 10–90 | 0.005 (0.000) | 0.034 (0.082) | 0.041 (0.147) | 0.027 (0.192) | 0.993 | 0.932 | 0.892 | 0.854 |
20–90 | 0.003 (0.000) | 0.012 (0.038) | 0.004 (0.067) | 0.043 (0.183) | 0.993 | 0.963 | 0.942 | 0.859 | |
30–90 | 0.002 (0.000) | 0.008 (0.032) | 0.002 (0.055) | 0.036 (0.168) | 0.993 | 0.968 | 0.949 | 0.866 | |
40–90 | 0.001 (0.000) | 0.008 (0.030) | 0.003 (0.054) | 0.048 (0.173) | 0.993 | 0.970 | 0.950 | 0.858 | |
50–90 | 0.001 (0.000) | 0.007 (0.031) | 0.003 (0.054) | 0.045 (0.174) | 0.993 | 0.970 | 0.949 | 0.858 | |
60–90 | 0.001 (0.000) | 0.008 (0.030) | 0.003 (0.053) | 0.046 (0.169) | 0.993 | 0.969 | 0.951 | 0.863 | |
70–90 | 0.001 (0.000) | 0.007 (0.031) | 0.004 (0.051) | 0.045 (0.165) | 0.993 | 0.969 | 0.953 | 0.868 | |
80–90 | 0.000 (0.000) | 0.008 (0.030) | 0.000 (0.050) | 0.043 (0.163) | 1.000 | 0.969 | 0.954 | 0.867 | |
90–90 | 0.000 (0.000) | 0.008 (0.028) | 0.001 (0.045) | 0.057 (0.179) | 1.000 | 0.970 | 0.959 | 0.861 | |
BPND V | 10–90 | 0.006 (0.000) | 0.023 (0.082) | 0.005 (0.145) | 0.117 (0.111) | 0.988 | 0.929 | 0.885 | 0.852 |
20–90 | 0.004 (0.000) | 0.001 (0.042) | 0.004 (0.090) | 0.011 (0.179) | 0.993 | 0.960 | 0.925 | 0.850 | |
30–90 | 0.002 (0.000) | 0.000 (0.037) | 0.014 (0.074) | 0.015 (0.179) | 0.993 | 0.965 | 0.938 | 0.851 | |
40–90 | 0.001 (0.000) | 0.001 (0.034) | 0.014 (0.072) | 0.019 (0.168) | 0.993 | 0.968 | 0.940 | 0.853 | |
50–90 | 0.001 (0.000) | 0.001 (0.034) | 0.015 (0.071) | 0.018 (0.164) | 0.993 | 0.968 | 0.940 | 0.855 | |
60–90 | 0.001 (0.000) | 0.001 (0.034) | 0.015 (0.071) | 0.008 (0.173) | 0.993 | 0.968 | 0.940 | 0.849 | |
70–90 | 0.001 (0.000) | 0.001 (0.033) | 0.012 (0.072) | 0.010 (0.163) | 0.993 | 0.968 | 0.939 | 0.856 | |
80–90 | 0.000 (0.000) | 0.001 (0.031) | 0.008 (0.067) | 0.006 (0.172) | 1.000 | 0.969 | 0.943 | 0.849 | |
90–90 | 0.000 (0.000) | 0.001 (0.029) | 0.004 (0.061) | 0.002 (0.150) | 1.000 | 0.971 | 0.949 | 0.867 | |