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Table 1 Pharmacokinetic parameters for simulating TACs using 2T4k_Vb

From: Optimized dual-time-window protocols for quantitative [18F]flutemetamol and [18F]florbetaben PET studies

 

[18F]flutemetamol

[18F]florbetaben

Level

BPND

k 3

BPND

k 3

BPND I

0.380

0.008

1.000

0.010

BPND II

0.635

0.013

1.500

0.015

BPND III

0.890

0.018

2.000

0.020

BPND IV

1.145

0.023

2.500

0.025

BPND V

1.400

0.028

3.000

0.030

 

\( {\mathrm{BP}}_{\mathrm{ND}}^{\mathrm{NS}} \)

k3

\( {\mathrm{BP}}_{\mathrm{ND}}^{\mathrm{NS}} \)

k 3

Reference

0.350

0.018

0.950

0.007

  1. BPND binding potential of target tissue, Vb had a constant value of 0.05. [18F]flutemetamol target tissue: K1 = 0.248, k2 = 0.08, reference tissue: K1 = 0.32, k2 = 0.103. [18F]florbetaben target tissue: K1 = 0.226, k2 = 0.069, reference tissue: K1 = 0.25, k2 = 0.076