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Table 4 Summary of simulation results for the oxidation parameter

From: Determination of a pharmacokinetic model for [11C]-acetate in brown adipose tissue

Model # Stability (%) Average accuracy (%) COV (%)
Cohort YS OS YS OS YS OS
1 < 1* < 1* − 12* − 12*** 11* 17*
2 − 41 − 76 429 − 27 89 86
3 16 − 43 280 − 16 152 85
4 < 1* < 1* 16** 8* 31*** 37***
5 212 258 150 90 96 85
6 − 72 − 31 − 75 − 29 108 105
7 < 1* < 1* − 29*** − 11** 32 39
8 53 2435 163 2546 132 156
9 − 22 − 65 − 30 − 68 15** 64
10 − 32 − 10 − 31 − 81 53 27**
  1. Stability: maximum percent difference between the oxidation parameter derived by fitting the noiseless curve and the ground truth. Average accuracy: maximum percent difference between the average oxidation parameter derived by fitting 100 noisy curves and the ground truth. COV coefficient of variation (standard deviation/mean) for 100 noisy curve fits. For each metric and each cohort, the 3 best (lowest) values are indicated (*best result, **second best, ***third best). YS younger subjects, OS older subjects