Determination of a pharmacokinetic model for [11C]-acetate in brown adipose tissue

EJNMMI Research

Table 4 Summary of simulation results for the oxidation parameter

Model #	Stability (%)		Average accuracy (%)		COV (%)
Cohort	YS	OS	YS	OS	YS	OS
1	< 1*	< 1*	− 12*	− 12***	11*	17*
2	− 41	− 76	429	− 27	89	86
3	16	− 43	280	− 16	152	85
4	< 1*	< 1*	16**	8*	31***	37^***
5	212	258	150	90	96	85
6	− 72	− 31	− 75	− 29	108	105
7	< 1*	< 1*	− 29***	− 11**	32	39
8	53	2435	163	2546	132	156
9	− 22	− 65	− 30	− 68	15^**	64
10	− 32	− 10	− 31	− 81	53	27**

Stability: maximum percent difference between the oxidation parameter derived by fitting the noiseless curve and the ground truth. Average accuracy: maximum percent difference between the average oxidation parameter derived by fitting 100 noisy curves and the ground truth. COV coefficient of variation (standard deviation/mean) for 100 noisy curve fits. For each metric and each cohort, the 3 best (lowest) values are indicated (*best result, **second best, ***third best). YS younger subjects, OS older subjects