Fig. 3
From: Determination of a pharmacokinetic model for [11C]-acetate in brown adipose tissue
Principal pathways of [11C]-acetate metabolism in BAT cells. In reality, the imaging voxel (4 mm3) comprises many cells and blood vessels. [11C]-acetate exchanges rapidly through the capillary wall [18] and is transported into the cell by monocarboxylate transporters [35]. It is then converted to [11C]-acetyl-CoA by acetyl-CoA synthase. [11C]-acetyl-CoA is a substrate for both the TCA cycle (oxidation) in the mitochondrion and for fatty acid synthesis