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Table 3 Tumor-to-tissue ratios of 18F-FLT and 18F-FDG at three different times post injection after i.t. infusion of 5 MBq into a single tumor

From: Intratumoral 18F-FLT infusion in metabolic targeted radiotherapy

Tissue Time Primary tumor Contralateral tumor
(min) 18F-FLT 18F-FDG 18F-FLT 18F-FDG
Kidneys 30 111 ± 45 50.2 ± 4.5 0.49 ± 0.21 0.16 ± 0.04
60 53 ± 25 19.9 ± 0.5 0.96 ± 0.48 0.18 ± 0.01
120 23 ± 19 14.2 ± 6.3 1.56 ± 0.75 0.26 ± 0.02
Liver 30 162 ± 90 135 ± 21 0.66 ± 0.19 0.41 ± 0.07
60 69 ± 33 71.4 ± 3.4 1.17 ± 0.41 0.63 ± 0.06
120 26 ± 17 49 ± 14 1.84 ± 0.58 0.92 ± 0.08
Brain 30 1100 ± 656 129 ± 41 4.42 ± 1.21 0.39 ± 0.01
60 334 ± 207 40.8 ± 6.3 5.37 ± 1.17 0.36 ± 0.04
120 105 ± 50 19.8 ± 6.7 7.62 ± 2.04 0.36 ± 0.02
Heart 30 155 ± 88 46 ± 41 0.63 ± 0.18 0.13 ± 0.08
60 70 ± 34 13.4 ± 13.1 1.18 ± 0.37 0.11 ± 0.11
120 28 ± 17 3.8 ± 2.8 1.96 ± 0.58 0.09 ± 0.08
  1. The ratios were determined from PET image-derived uptakes of the radiotracers