- aControl animals received 0.9% NaCl solution
- bThe single i.t. infusion of 2.5 mg 5FU was administered 4 h prior i.t. infusion of 18F-FLT or 18F-FDG, or of a single 15 Gy dose EBRT
- cFive times tumor growth delay (5Td) was determined as the time required for the tumor volume to increase fivefold over the initial volume at the start of treatment
- dTumor growth delay (TGD) = 5Td of the treated group – 5Td of the non-treated group
- eThe enhancement factor (EF) = 5Td of the treated group/5Td of the non-treated group
- fGrowth of contralateral tumors after i.t. 18F-FLT 10 MBq into the primary tumor
- g5TD p value of each treatment conditions in comparison with the control group, One-way ANOVA, F(10,27) = 130.2, p < 0.0001, Dunnett’s test and comparison of (i.t. 5FU + 15 Gy EBRT) with (i.t. 5FU + i.t. 18F-FLT 15 MBq) and (i.t. 5FU + i.t. 18F-FDG 15 MBq) Tukey’s multiple comparison test. ns: p > 0.05; *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001 ****p ≤ 0.0001. Two to four animals were included in each group