99mTc-labeled BN analog | Organs | 5 min | 30 min | 60 min | 60 min (blocked) | 120 min |
---|---|---|---|---|---|---|
(99mTc-BNS) | Blood | 1.25 ± 0.05 | 1.02 ± 0.03 | 0.82 ± 0.01 | 0.84 ± 0.01 | 0.54 ± 0.01 |
Liver | 1.60 ± 0.07 | 0.85 ± 0.06 | 0.40 ± 0.05 | 0.42 ± 0.04 | 0.22 ± 0.02 | |
Heart | 1.80 ± 0.02 | 1.10 ± 0.01 | 0.79 ± 0.12 | 0.77 ± 0.11 | 0.50 ± 0.01 | |
Lung | 1.35 ± 0.04 | 0.84 ± 0.11 | 0.68 ± 0.03 | 0.70 ± 0.05 | 0.33 ± 0.02 | |
Kidney | 2.86 ± 0.10 | 3.12 ± 0.20 | 2.82 ± 0.16 | 2.88 ± 0.12 | 2.40 ± 0.12 | |
Intestine | 0.84 ± 0.03 | 0.52 ± 0.05 | 0.31 ± 0.02 | 0.36 ± 0.02 | 0.22 ± 0.01 | |
Spleen | 0.22 ± 0.04 | 0.18 ± 0.03 | 0.11 ± 0.02 | 0.10 ± 0.03 | 0.06 ± 0.11 | |
Pancreas | 0.88 ± 0.01 | 1.73 ± 0.10 | 1.14 ± 0.05 | 0.90 ± 0.02 | 0.95 ± 0.04 | |
Stomach | 0.76 ± 0.03 | 0.69 ± 0.05 | 0.46 ± 0.04 | 0.45 ± 0.01 | 0.12 ± 0.02 | |
Muscle | 0.16 ± 0.03 | 0.26 ± 0.02 | 0.18 ± 0.04 | 0.17 ± 0.03 | 0.11 ± 0.02 | |
Tumor | 0.45 ± 0.12 | 0.95 ± 0.05 | 0.75 ± 0.04 | 0.68 ± 0.20 | 0.58 ± 0.01 | |
Urine + urinary bladder | 0.56 ± 0.02 | 1.92 ± 0.07 | 2.54 ± 0.22 | 2.58 ± 0.18 | 2.85 ± 0.03 | |
(99mTc-BN1) | Blood | 1.32 ± 0.07 | 0.89 ± 0.04 | 0.32 ± 0.01 | 0.34 ± 0.01 | 0.05 ± 0.01 |
Liver | 0.85 ± 0.04 | 0.69 ± 0.03 | 0.56 ± 0.02 | 0.55 ± 0.03 | 0.32 ± 0.01 | |
Heart | 1.02 ± 0.05 | 0.81 ± 0.04 | 0.47 ± 0.02 | 0.44 ± 0.01 | 0.17 ± 0.01 | |
Lung | 0.95 ± 0.04 | 0.77 ± 0.03 | 0.56 ± 0.02 | 0.57 ± 0.02 | 0.32 ± 0.01 | |
Kidney | 2.12 ± 0.10 | 4.12 ± 0.20 | 3.15 ± 0.15 | 3.10 ± 0.02 | 1.56 ± 0.07 | |
Intestine | 1.06 ± 0.05 | 1.36 ± 0.06 | 1.70 ± 0.08 | 1.44 ± 0.05 | 1.10 ± 0.05 | |
Spleen | 0.94 ± 0.04 | 0.51 ± 0.02 | 0.32 ± 0.01 | 0.35 ± 0.01 | 0.26 ± 0.03 | |
Pancreas | 2.58 ± 0.12 | 1.79 ± 0.08 | 1.11 ± 0.05 | 0.91 ± 0.04 | 0.69 ± 0.03 | |
Stomach | 0.42 ± 0.02 | 0.85 ± 0.04 | 0.56 ± 0.02 | 0.40 ± 0.02 | 0.35 ± 0.01 | |
Muscle | 0.22 ± 0.02 | 0.27 ± 0.01 | 0.14 ± 0.01 | 0.16 ± 0.02 | 0.09 ± 0.02 | |
Tumor | 0.78 ± 0.03 | 2.51 ± 0.12 | 1.85 ± 0.09 | 1.20 ± 0.03 | 1.56 ± 0.07 | |
Urine + urinary bladder | 0.81 ± 0.04 | 2.85 ± 0.01 | 3.50 ± 0.15 | 3.56 ± 0.02 | 4.79 ± 0.12 | |
(99mTc-BN2) | Blood | 1.03 ± 0.05 | 0.78 ± 0.03 | 0.35 ± 0.01 | 0.38 ± 0.01 | 0.07 ± 0.01 |
Liver | 1.47 ± 0.07 | 1.23 ± 0.06 | 1.01 ± 0.05 | 1.09 ± 0.04 | 0.53 ± 0.02 | |
Heart | 0.59 ± 0.02 | 0.46 ± 0.01 | 0.23 ± 0.12 | 0.27 ± 0.02 | 0.12 ± 0.01 | |
Lung | 0.91 ± 0.04 | 0.89 ± 0.11 | 0.78 ± 0.03 | 0.73 ± 0.04 | 0.42 ± 0.02 | |
Kidney | 2.05 ± 0.10 | 4.76 ± 0.20 | 3.34 ± 0.16 | 3.37 ± 0.10 | 2.45 ± 0.12 | |
Intestine | 0.73 ± 0.03 | 1.05 ± 0.05 | 1.46 ± 0.02 | 1.25 ± 0.02 | 0.18 ± 0.01 | |
Spleen | 0.95 ± 0.04 | 0.75 ± 0.03 | 0.48 ± 0.02 | 0.45 ± 0.03 | 0.24 ± 0.11 | |
Pancreas | 0.95 ± 0.01 | 2.07 ± 0.10 | 1.08 ± 0.05 | 0.85 ± 0.02 | 0.89 ± 0.04 | |
Stomach | 0.74 ± 0.03 | 1.01 ± 0.05 | 0.82 ± 0.04 | 0.70 ± 0.02 | 0.41 ± 0.02 | |
Muscle | 0.24 ± 0.01 | 0.20 ± 0.02 | 0.18 ± 0.03 | 0.20 ± 0.02 | 0.12 ± 0.04 | |
Tumor | 0.79 ± 0.12 | 1.85 ± 0.05 | 0.98 ± 0.04 | 0.78 ± 0.03 | 0.54 ± 0.02 | |
Urine + urinary bladder | 0.56 ± 0.02 | 1.92 ± 0.07 | 4.54 ± 0.22 | 4.50 ± 0.08 | 5.55 ± 0.03 | |
(99mTc-BN3) | Blood | 0.54 ± 0.01 | 0.85 ± 0.01 | 0.47 ± 0.04 | 0.30 ± 0.01 | 0.24 ± 0.01 |
Liver | 0.44 ± 0.03 | 0.23 ± 0.13 | 0.18 ± 0.12 | 0.20 ± 0.03 | 0.11 ± 0.03 | |
Heart | 0.91 ± 0.03 | 0.77 ± 0.02 | 0.35 ± 0.02 | 0.29 ± 0.11 | 0.15 ± 0.04 | |
Lung | 0.87 ± 0.14 | 0.62 ± 0.03 | 0.50 ± 0.02 | 0.52 ± 0.02 | 0.35 ± 0.11 | |
Kidney | 1.97 ± 0.11 | 3.88 ± 0.21 | 3.17 ± 0.17 | 3.18 ± 0.20 | 1.40 ± 0.13 | |
Intestine | 1.21 ± 0.06 | 1.46 ± 0.05 | 1.85 ± 0.21 | 1.36 ± 0.23 | 0.70 ± 0.05 | |
Spleen | 0.54 ± 0.04 | 0.46 ± 0.01 | 0.30 ± 0.01 | 0.33 ± 0.03 | 0.12 ± 0.02 | |
Pancreas | 2.78 ± 0.11 | 3.59 ± 0.03 | 2.11 ± 0.06 | 0.92 ± 0.02 | 1.22 ± 0.04 | |
Stomach | 0.52 ± 0.02 | 0.74 ± 0.04 | 0.66 ± 0.02 | 0.37 ± 0.10 | 0.25 ± 0.01 | |
Muscle | 0.50 ± 0.01 | 0.30 ± 0.02 | 0.26 ± 0.03 | 0.16 ± 0.21 | 0.19 ± 0.02 | |
Tumor | 1.28 ± 0.01 | 2.95 ± 0.01 | 2.70 ± 0.02 | 0.54 ± 0.20 | 1.69 ± 0.03 | |
Urine + urinary bladder | 0.61 ± 0.04 | 2.80 ± 0.01 | 3.75 ± 0.11 | 3.52 ± 0.07 | 3.91 ± 0.22 | |
(99mTc-BN4) | Blood | 0.42 ± 0.01 | 0.81 ± 0.01 | 0.42 ± 0.03 | 0.29 ± 0.01 | 0.17 ± 0.00 |
Liver | 0.40 ± 0.03 | 0.52 ± 0.13 | 0.28 ± 0.12 | 0.25 ± 0.03 | 0.17 ± 0.03 | |
Heart | 0.73 ± 0.03 | 0.67 ± 0.02 | 0.25 ± 0.02 | 0.27 ± 0.11 | 0.09 ± 0.04 | |
Lung | 1.07 ± 0.14 | 0.82 ± 0.03 | 0.70 ± 0.02 | 0.78 ± 0.02 | 0.25 ± 0.11 | |
Kidney | 2.17 ± 0.11 | 3.95 ± 0.21 | 3.10 ± 0.17 | 3.18 ± 0.20 | 2.10 ± 0.13 | |
Intestine | 1.01 ± 0.06 | 1.60 ± 0.05 | 2.15 ± 0.21 | 1.66 ± 0.23 | 0.82 ± 0.05 | |
Spleen | 0.62 ± 0.04 | 0.56 ± 0.01 | 0.24 ± 0.01 | 0.26 ± 0.03 | 0.17 ± 0.02 | |
Pancreas | 2.88 ± 0.11 | 4.49 ± 0.03 | 3.75 ± 0.06 | 1.98 ± 0.02 | 1.10 ± 0.04 | |
Stomach | 0.47 ± 0.02 | 0.91 ± 0.04 | 0.76 ± 0.02 | 0.63 ± 0.10 | 0.20 ± 0.01 | |
Muscle | 0.26 ± 0.02 | 0.32 ± 0.04 | 0.25 ± 0.02 | 0.13 ± 0.10 | 0.10 ± 0.01 | |
Tumor | 1.30 ± 0.01 | 3.32 ± 0.01 | 2.85 ± 0.02 | 0.66 ± 0.20 | 1.31 ± 0.03 | |
Urine + urinarybladder | 0.47 ± 0.04 | 2.65 ± 0.01 | 3.92 ± 0.11 | 3.95 ± 0.07 | 4.31 ± 0.22 |