HYNIC and DOMA conjugated radiolabeled bombesin analogs as receptor-targeted probes for scintigraphic detection of breast tumor

EJNMMI Research

Table 1 In vitro stability of ^99mTc-BN3, ^99mTc-BN4, and ^99mTc-BNS in PBS and FBS after incubation for 2 to 24 h at 37 °C. Data were expressed as the mean ± SD

Time	% of radiolabeled peptides remaining
	In FBS			In PBS
	^99mTc-BN4	^99mTc-BN3	^99mTc-BNS	^99mTc-BN4	^99mTc-BN3	^99mTc-BNS
2 h	98.30 ± 0.10	97.50 ± 0.05	96.00 ± 0.04	95.50 ± 0.03	93.21 ± 0.20	94.31 ± 0.04
4 h	97.60 ± 0.05	97.00 ± 0.06	95.50 ± 0.07	95.00 ± 0.07	90.13 ± 0.05	90.22 ± 0.21
6 h	97.00 ± 0.18	96.50 ± 0.15	94.30 ± 0.12	93.50 ± 0.12	89.02 ± 0.07	86.10 ± 0.18
8 h	96.40 ± 0.20	95.00 ± 0.12	93.50 ± 0.18	92.50 ± 0.20	87.11 ± 0.12	82.14 ± 0.11
12 h	95.20 ± 0.05	94.00 ± 0.20	92.20 ± 0.05	90.00 ± 0.11	84.01 ± 0.21	80.10 ± 0.07
24 h	93.30 ± 0.02	90.00 ± 0.24	91.00 ± 0.07	88.00 ± 0.14	80.21 ± 0.16	77.17 ± 0.05