Table 2 Relative changes (%) in kinetic parameter estimates and simplified metrics after PVC

11.8

13.2

7.1

6.0–16.4

− 15.2

25.1

< 0.001

6.6

6.8

7.5

2.6–11.1

− 16.7

32.3

< 0.001

6.1

6.0

8.8

2.1–10.7

− 21.9

34.6

< 0.001

13.1

13.2

6.1

7.3–17.1

3.3

28.4

< 0.001

13.1

13.2

6.1

7.3–17.1

3.3

28.3

< 0.001

10.8

11.7

6.1

6.1–15.5

− 13.6

21.7

< 0.001

5.7

4.3

6.9

2.3–10.0

− 14.9

25.1

< 0.001

3.7

4.4

6.4

0.1–7.1

− 20.6

19.8

< 0.001

12.6

12.9

5.8

7.0–16.7

2.1

24.7

< 0.001

12.8

12.9

6.0

7.0–17.0

3.1

27.3

< 0.001