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Fig. 2 | EJNMMI Research

Fig. 2

From: First-in-class positron emission tomography tracer for the glucagon receptor

Fig. 2

Cellular internalization and GCGR affinity of [68Ga]Ga-DO3A-S01-GCG and [68Ga]Ga-DO3A-S02-GCG. Binding and internalization in HEK293 cells overexpressing human GCGR of [68Ga]Ga-DO3A-S01-GCG (a) and [68Ga]Ga-DO3A-S02-GCG (b). Internalization was suppressed by cooling cells to 4 °C. Affinity was measured in HEK293 cells overexpressing human GCGR by saturation binding studies on viable cells (c, d) or by in vitro autoradiography (ARG) on sections of cell pellet (e)

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