Fig. 2From: First-in-class positron emission tomography tracer for the glucagon receptorCellular internalization and GCGR affinity of [68Ga]Ga-DO3A-S01-GCG and [68Ga]Ga-DO3A-S02-GCG. Binding and internalization in HEK293 cells overexpressing human GCGR of [68Ga]Ga-DO3A-S01-GCG (a) and [68Ga]Ga-DO3A-S02-GCG (b). Internalization was suppressed by cooling cells to 4 °C. Affinity was measured in HEK293 cells overexpressing human GCGR by saturation binding studies on viable cells (c, d) or by in vitro autoradiography (ARG) on sections of cell pellet (e)Back to article page