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Table 3 Comparative results following insulin administration patients in Cohort 1, Cohort 2 (ITT) and Cohort 2 (PP) groups

From: Personalised insulin calculator enables safe and effective correction of hyperglycaemia prior to FDG PET/CT

Outcome Cohort 1
N = 115
Cohort 2 (ITT)
N = 136
P value* Cohort 2 (PP)
N = 103
P value#
Hypoglycaemia (BGL < 3.5 mmol/L) 6 (5.2%) 1 (0.7%) < 0.03 0 (0%) < 0.019
Mean BGL at time of FDG, mmol/L 9.0 ± 2.6 8.6 ± 2.3 NS 8.6 ± 2.2 NS
Insulin dose prescribed, IU 12 ± 4.1 11.1 ± 5.1 NS 10.5 ± 4.9 NS
Mean BGL decline, mmol/L 7.1 ± 2.8 6.8 ± 2.9 NS 6.8 ± 2.9 NS
Achieved BGL ≤ 10.0 mmol/L, N (%) 92 (80%) 116 (85.3%) 0.27 91 (88.3%) 0.095
Repeat insulin dosage, N (%) 17 (14.8%) 10 (7.4%) 0.06 7 (6.8%) 0.06
Time from insulin to FDG injection, min      
- Median 136 108 < 0.001 108 < 0.001
- Range 68–287 70–237   75–237  
  1. ITT intention to treat, PP per protocol, N number, BGL blood glucose level, IU international units of human insulin, NS not significant (P > 0.05); *unpaired t-test between Cohort 1 and Cohort 2 ITT group, #unpaired t-test between Cohort 1 and Cohort 2 PP group