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Table 4 Total radioligand binding (VT ± standard error) in lungs and pituitary gland; ipratropium inhalation dose and average plasma exposure

From: Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

NHP Lungs Pituitary gland Ipratropium post-dosing
Baseline VT (ml/cm3) Post-dosing VT (ml/cm3) Baseline VT (ml/cm3) Post-dosing VT (ml/cm3) Dose (μg/kg) Exposure, Cpl (nM)
#1 0.32 ± 0.007 0.43 ± 0.005 2.08 ± 0.195 1.79 ± 0.166 1.5 0.55
#1 0.95 ± 0.012 0.29 ± 0.002 2.63 ± 0.202 0.42 ± 0.041 2.0 3.46
#3 0.52 ± 0.004 0.13 ± 0.001 0.91 ± 0.174 0.20 ± 0.071 150.0 19.36
#5 0.81 ± 0.010 0.59 ± 0.009 0.82 ± 0.251 0.63 ± 0.230 0.5 (0.25)a
#5 0.68 ± 0.013 0.11 ± 0.002 1.42 ± 0.348 0.17 ± 0.218 10.0 8.06
  1. aPlasma exposure could not be measured, lower limit-of-quantification value used for model fitting