Table 4 Total radioligand binding (VT ± standard error) in lungs and pituitary gland; ipratropium inhalation dose and average plasma exposure
From: Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator
NHP | Lungs | Pituitary gland | Ipratropium post-dosing | |||
|---|---|---|---|---|---|---|
Baseline VT (ml/cm3) | Post-dosing VT (ml/cm3) | Baseline VT (ml/cm3) | Post-dosing VT (ml/cm3) | Dose (μg/kg) | Exposure, Cpl (nM) | |
#1 | 0.32 ± 0.007 | 0.43 ± 0.005 | 2.08 ± 0.195 | 1.79 ± 0.166 | 1.5 | 0.55 |
#1 | 0.95 ± 0.012 | 0.29 ± 0.002 | 2.63 ± 0.202 | 0.42 ± 0.041 | 2.0 | 3.46 |
#3 | 0.52 ± 0.004 | 0.13 ± 0.001 | 0.91 ± 0.174 | 0.20 ± 0.071 | 150.0 | 19.36 |
#5 | 0.81 ± 0.010 | 0.59 ± 0.009 | 0.82 ± 0.251 | 0.63 ± 0.230 | 0.5 | (0.25)a |
#5 | 0.68 ± 0.013 | 0.11 ± 0.002 | 1.42 ± 0.348 | 0.17 ± 0.218 | 10.0 | 8.06 |