From: Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator
NHP | Lungs | Pituitary gland | Ipratropium post-dosing | |||
---|---|---|---|---|---|---|
Baseline VT (ml/cm3) | Post-dosing VT (ml/cm3) | Baseline VT (ml/cm3) | Post-dosing VT (ml/cm3) | Dose (μg/kg) | Exposure, Cpl (nM) | |
#1 | 2.29 ± 0.019 | 0.35 ± 0.003 | 4.09 ± 0.272 | 0.20 ± 0.039 | 30.0 | 221.59 |
#2 | 0.39 ± 0.002 | 0.29 ± 0.001 | 1.48 ± 0.111 | 0.45 ± 0.046 | 2.0 | 5.93 |
#3 | 1.33 ± 0.011 | 0.30 ± 0.006 | 4.26 ± 0.346 | 0.42 ± 0.070 | 10.0 | 43.65 |
#4 | 0.66 ± 0.005 | 0.44 ± 0.003 | 5.93 ± 0.626 | 1.14 ± 0.131 | 2.0 | 7.09 |