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Table 3 Total radioligand binding (VT ± standard error) in the lungs and pituitary glands; ipratropium intravenous infusion dose and plasma exposure

From: Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

NHP

Lungs

Pituitary gland

Ipratropium post-dosing

Baseline VT (ml/cm3)

Post-dosing VT (ml/cm3)

Baseline VT (ml/cm3)

Post-dosing VT (ml/cm3)

Dose (μg/kg)

Exposure, Cpl (nM)

#1

2.29 ± 0.019

0.35 ± 0.003

4.09 ± 0.272

0.20 ± 0.039

30.0

221.59

#2

0.39 ± 0.002

0.29 ± 0.001

1.48 ± 0.111

0.45 ± 0.046

2.0

5.93

#3

1.33 ± 0.011

0.30 ± 0.006

4.26 ± 0.346

0.42 ± 0.070

10.0

43.65

#4

0.66 ± 0.005

0.44 ± 0.003

5.93 ± 0.626

1.14 ± 0.131

2.0

7.09