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Table 3 Total radioligand binding (VT ± standard error) in the lungs and pituitary glands; ipratropium intravenous infusion dose and plasma exposure

From: Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

NHP Lungs Pituitary gland Ipratropium post-dosing
Baseline VT (ml/cm3) Post-dosing VT (ml/cm3) Baseline VT (ml/cm3) Post-dosing VT (ml/cm3) Dose (μg/kg) Exposure, Cpl (nM)
#1 2.29 ± 0.019 0.35 ± 0.003 4.09 ± 0.272 0.20 ± 0.039 30.0 221.59
#2 0.39 ± 0.002 0.29 ± 0.001 1.48 ± 0.111 0.45 ± 0.046 2.0 5.93
#3 1.33 ± 0.011 0.30 ± 0.006 4.26 ± 0.346 0.42 ± 0.070 10.0 43.65
#4 0.66 ± 0.005 0.44 ± 0.003 5.93 ± 0.626 1.14 ± 0.131 2.0 7.09