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Table 4 ROC analysis for discriminating responders from non-responders using FDG and 4DST PET parameters

From: Efficacy of 4′-[methyl-11C] thiothymidine PET/CT before and after neoadjuvant therapy for predicting therapeutic responses in patients with esophageal cancer: a pilot study

Parameters

AUC (95% CI)

Optimal cutoff value

Sensitivity

Specificity

Accuracy

PPV

NPV

FDG

preSUVmax

0.78 (0.58–0.98)

≥ 10.7

0.600

0.938

0.808

0.857

0.789

 ΔSUVmax (%)

0.92 (0.78–1.00)

≤ − 60.3

0.900

0.875

0.885

0.818

0.933

 ΔTLG (%)

0.78 (0.56–0.99)

≤ − 84.7

0.800

0.812

0.808

0.727

0.867

4DST

postSUVmax

0.88 (0.75–1.00)

≤ 4.00

1.000

0.625

0.769

0.625

1.000

 ΔSUVmax (%)

0.92 (0.80–1.00)

≤ − 19.5

0.900

0.938

0.923

0.900

0.938

 ΔTLP (%)

0.78 (0.57–0.99)

≤ − 86.7

0.800

0.812

0.808

0.727

0.867

  1. SUVmax maximum standardized uptake value, MTV metabolic tumor volume, TLG total lesion glycolysis, TLP total lesion proliferation, PPV positive predictive value, NPV negative predictive value