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Table 4 ROC analysis for discriminating responders from non-responders using FDG and 4DST PET parameters

From: Efficacy of 4′-[methyl-11C] thiothymidine PET/CT before and after neoadjuvant therapy for predicting therapeutic responses in patients with esophageal cancer: a pilot study

Parameters AUC (95% CI) Optimal cutoff value Sensitivity Specificity Accuracy PPV NPV
FDG
preSUVmax 0.78 (0.58–0.98) ≥ 10.7 0.600 0.938 0.808 0.857 0.789
 ΔSUVmax (%) 0.92 (0.78–1.00) ≤ − 60.3 0.900 0.875 0.885 0.818 0.933
 ΔTLG (%) 0.78 (0.56–0.99) ≤ − 84.7 0.800 0.812 0.808 0.727 0.867
4DST
postSUVmax 0.88 (0.75–1.00) ≤ 4.00 1.000 0.625 0.769 0.625 1.000
 ΔSUVmax (%) 0.92 (0.80–1.00) ≤ − 19.5 0.900 0.938 0.923 0.900 0.938
 ΔTLP (%) 0.78 (0.57–0.99) ≤ − 86.7 0.800 0.812 0.808 0.727 0.867
  1. SUVmax maximum standardized uptake value, MTV metabolic tumor volume, TLG total lesion glycolysis, TLP total lesion proliferation, PPV positive predictive value, NPV negative predictive value