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Fig. 2 | EJNMMI Research

Fig. 2

From: Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 68Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques

Fig. 2

In vivo imaging and tracer uptake quantification in the atherosclerotic plaques. In vivo PET/CT images from ApoE-KO non-blocked, blocked and control mice were acquired 1 h p.i. of 68Ga-NOTA-anti-MMR Nb (a). Note the intense focal signals in the atherosclerotic plaques of ApoE-KO non-blocked mice (blue arrows). In contrast, no focal uptake was detected in the aortas of ApoE-KO mice after blocking with an excess amount of non-labelled NOTA-anti-MMR Nb or in the aortas of control mice. The upper threshold is reduced in order to reveal focal uptake, which resulted in exaggerated abdominal area signals. H heart, Li liver, Ki kidney, Bl bladder. Plaque signal intensities were quantified in thoracic and abdominal aorta using axial PET/CT images (b)

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