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Table 3 Difference in parameters with PFS > 4 months versus PFS ≤ 4 months

From: 18F-FDG and 11C-4DST PET/CT for evaluating response to platinum-based doublet chemotherapy in advanced non-small cell lung cancer: a prospective study

Modality

Parameters

PFS ≤ 4 months

PFS > 4 months

p value

CT

Sum of uni-dimensional measurements of target lesions (cm)

74.6 ± 42.8

69.2 ± 23.2

0.87

FDG

Highest SUVmax

12.8 ± 5.6

11.7 ± 4.4

0.95

Sum of SUVmax

38.8 ± 41.6

28.6 ± 21.4

0.90

MTV

138.0 ± 129.0

57.6 ± 43.5

0.19

TLG

707.9 ± 701.7

292.3 ± 240.7

0.21

SUL

10.0 ± 4.8

7.6 ± 3.3

0.28

%Δhighest SUVmax

− 12.2 ± 37.8

− 12.0 ± 80.7

0.42

%Δsum of SUVmax

− 19.2 ± 39.8

− 6.4 ± 85.1

0.79

%ΔMTV

− 10.4 ± 59.4

− 29.1 ± 45.8

0.42

%ΔTLG

− 10.9 ± 99.7

− 32.4 ± 79.0

0.33

%ΔSUL

− 26.8 ± 47.5

− 34.4 ± 66.1

0.39

4DST

Highest SUVmax

6.8 ± 2.4

5.7 ± 1.7

0.11

Sum of SUVmax

19.4 ± 17.8

22.8 ± 21.0

0.84

MTV

127.7 ± 127.8

50.3 ± 29.2

0.06

TLP

384.4 ± 371.0

158.4 ± 116.0

0.09

%Δhighest SUVmax

11.9 ± 37.3

− 5.6 ± 47.9

0.33

%Δsum of SUVmax

9.1 ± 49.5

− 18.6 ± 56.9

0.19

%ΔMTV

− 18.9 ± 45.7

− 36.9 ± 52.4

0.33

%ΔTLP

− 5.2 ± 77.9

− 32.9 ± 60.3

0.37

  1. MTV metabolic tumor volume, TLG total lesion glycolysis, SUL standardized uptake value normalized by lean body mass, TLP total lesion proliferation