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Table 1 Mean (±SD) values for SUVR and Centiloid generated for paired PiB and [18F]flutemetamol using three different image process pipelines; SPM8, PMOD and FSL. Centiloid values for PMOD and FSL have not been corrected to ‘Standard’ (SPM8-equivalent) CL. For the variance ratio, SPM8-derived CL for young healthy controls were used as the gold standard

From: Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods

 

[11C]PiB

[18F]flutemetamol*

Variance ratio# (Centiloid)

SUVR

Centiloid

PiB-CalcSUVR

Centiloid

Young healthy controls (n = 24)

 SPM8

1.008 (0.065)

−0.6 (6.1)

1.003 (0.077)

−1.0 (7.2)

1.19

 PMOD

0.967 (0.069)

−0.9 (6.3)

0.957 (0.079)

−1.8 (7.2)

1.14

 FSL

1.003 (0.067)

2.4 (6.2)

1.000 (0.080)

2.2 (7.3)

1.18

Other (n = 50)

 SPM8

1.565 (0.528)

51.4 (49.2)

1.567 (0.539)

51.6 (50.3)

1.02

 PMOD

1.549 (0.533)

52.4 (48.7)

1.554 (0.541)

52.8 (49.5)

1.02

 FSL

1.575 (0.546)

54.8 (49.9)

1.577 (0.559)

54.9 (51.1)

1.02

  1. *PiB-Equivalent SUVR [18F]flutemetamol values. #Centiloid SD [18F]flutemetamol/Centiloid SD PiB