Test-retest reliability and convergent validity of (R)-[11C]PK11195 outcome measures without arterial input function

EJNMMI Research

Table 3 Test-retest metrics for BP_ND values from the SVCA4 method using two additional population-based kinetic classes, developed at VUMC and TPC, respectively

Method	Kinetic classes	Region	Mean	SD	ICC	AbsVar%	SEM	MD%
BP_NDSRTM-SVCA4	TPC	FC	0.28	0.08	− 0.06	28	0.08	82
	TPC	GM	0.32	0.09	− 0.06	28	0.09	76
	TPC	HIP	0.33	0.13	− 0.16	45	0.14	117
	TPC	STR	0.25	0.16	− 0.51	84	0.19	214
	TPC	THAL	0.55	0.27	0.11	62	0.26	129
	VUMC	FC	0.43	0.12	0.02	30	0.12	74
	VUMC	GM	0.46	0.11	− 0.18	30	0.12	74
	VUMC	HIP	0.36	0.14	− 0.28	52	0.16	122
	VUMC	STR	0.45	0.13	− 0.32	37	0.14	88
	VUMC	THAL	0.6	0.16	− 0.09	27	0.16	76
BP_NDSRTMv-SVCA4	TPC	FC	0.2	0.1	− 0.19	72	0.11	150
	TPC	GM	0.24	0.09	− 0.49	56	0.11	132
	TPC	HIP	0.25	0.07	− 0.46	39	0.09	101
	TPC	STR	0.23	0.09	0	46	0.09	105
	TPC	THAL	0.44	0.21	− 0.16	71	0.23	144
	VUMC	FC	0.37	0.1	0.21	25	0.09	67
	VUMC	GM	0.4	0.08	− 0.2	22	0.09	61
	VUMC	HIP	0.39	0.12	− 0.76	41	0.15	109
	VUMC	STR	0.46	0.31	0.02	65	0.31	184
	VUMC	THAL	0.63	0.14	0.22	24	0.12	53

TPC Turku PET Center, VUMC VU University Medical Center, FC frontal cortex, GM gray matter, HIP hippocampus, STR striatum, THAL thalamus, ICC intraclass correlation coefficient, AbsVar% percentage (of the mean) absolute variability, SEM standard error of the measurement, MD% percentage (of the mean) minimum detectable difference