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Table 3 Test-retest metrics for BPND values from the SVCA4 method using two additional population-based kinetic classes, developed at VUMC and TPC, respectively

From: Test-retest reliability and convergent validity of (R)-[11C]PK11195 outcome measures without arterial input function

Method Kinetic classes Region Mean SD ICC AbsVar% SEM MD%
BPND SRTM-SVCA4 TPC FC 0.28 0.08 − 0.06 28 0.08 82
TPC GM 0.32 0.09 − 0.06 28 0.09 76
TPC HIP 0.33 0.13 − 0.16 45 0.14 117
TPC STR 0.25 0.16 − 0.51 84 0.19 214
TPC THAL 0.55 0.27 0.11 62 0.26 129
VUMC FC 0.43 0.12 0.02 30 0.12 74
VUMC GM 0.46 0.11 − 0.18 30 0.12 74
VUMC HIP 0.36 0.14 − 0.28 52 0.16 122
VUMC STR 0.45 0.13 − 0.32 37 0.14 88
VUMC THAL 0.6 0.16 − 0.09 27 0.16 76
BPNDSRTMv-SVCA4 TPC FC 0.2 0.1 − 0.19 72 0.11 150
TPC GM 0.24 0.09 − 0.49 56 0.11 132
TPC HIP 0.25 0.07 − 0.46 39 0.09 101
TPC STR 0.23 0.09 0 46 0.09 105
TPC THAL 0.44 0.21 − 0.16 71 0.23 144
VUMC FC 0.37 0.1 0.21 25 0.09 67
VUMC GM 0.4 0.08 − 0.2 22 0.09 61
VUMC HIP 0.39 0.12 − 0.76 41 0.15 109
VUMC STR 0.46 0.31 0.02 65 0.31 184
VUMC THAL 0.63 0.14 0.22 24 0.12 53
  1. TPC Turku PET Center, VUMC VU University Medical Center, FC frontal cortex, GM gray matter, HIP hippocampus, STR striatum, THAL thalamus, ICC intraclass correlation coefficient, AbsVar% percentage (of the mean) absolute variability, SEM standard error of the measurement, MD% percentage (of the mean) minimum detectable difference