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Table 3 18F-FDG PET lesion parameters on a per-patient basis, stratified by LDH or BRAFV600 mutation status

From: Mapping heterogeneity in glucose uptake in metastatic melanoma using quantitative 18F-FDG PET/CT analysis

 

LDH groupsa

P

BRAFV600 groups

P

Normalb (n = 35)

Elevated (n = 28)

Wild-type (n = 33)

Mutant (n = 31)

No. of lesions

 All

13 (7–17)

46 (20–140)

< 0.001

17 (10–34)

18 (11–64)

0.510

 ≥ 1 mlc

4 (2–6)

17 (7–48)

< 0.001

6 (3–14)

6 (2–26)

0.984

SUVpeak

 Maximum

8.7 (4.4–13.1)

13.3 (7.1–23.5)

0.011

10.1 (5.6–18.9)

8.8 (5.2–13.9)

0.310

 Median

3.9 (2.7–7.4)

5.5 (3.5–8.9)

0.203

5.3 (3.3–9.0)

4.0 (3.2–8.3)

0.317

SUVpeak interquartile ranged

1.2 (0–3.3)

3.3 (1.5–6.7)

0.002

2.7 (0–5.1)

2.0 (0–4.7)

0.380

SUVmax

 Maximum

11.3 (6.1–16.6)

15.8 (9.0–27.7)

0.026

13.0 (7.3–22.2)

11.6 (7.2–17.4)

0.344

 Median

5.3 (3.7–9.4)

8.0 (4.9–12.0)

0.171

7.4 (4.5–11.7)

5.3 (4.0–11.7)

0.394

SUVmean

 Maximum

6.0 (4.1–8.7)

9.0 (6.1–15.4)

0.009

8.4 (4.7–12.3)

6.9 (4.7–8.8)

0.274

 Median

3.9 (2.8–6.2)

5.3 (3.4–7.6)

0.128

4.8 (3.2–7.9)

3.9 (2.9–7.1)

0.256

Total MATV (ml)

14 (6–65)

127 (29–512)

< 0.001

44 (10–185)

29 (13–238)

0.861

Total TLG

67 (18–448)

1180 (200–2998)

< 0.001

281 (43–1541)

199 (64–1568)

0.984

  1. Data are displayed as median (interquartile range)
  2. LDH lactate dehydrogenase
  3. aOne patient had a missing LDH value
  4. bThree patients with normal LDH had only lesions < 1 ml
  5. cAll lesions included in subsequent quantitative analyses
  6. dInterquartile range of the different SUVpeaks measured within one patient, measure of intra-patient heterogeneity