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Table 3 18F-FDG PET lesion parameters on a per-patient basis, stratified by LDH or BRAFV600 mutation status

From: Mapping heterogeneity in glucose uptake in metastatic melanoma using quantitative 18F-FDG PET/CT analysis

  LDH groupsa P BRAFV600 groups P
Normalb (n = 35) Elevated (n = 28) Wild-type (n = 33) Mutant (n = 31)
No. of lesions
 All 13 (7–17) 46 (20–140) < 0.001 17 (10–34) 18 (11–64) 0.510
 ≥ 1 mlc 4 (2–6) 17 (7–48) < 0.001 6 (3–14) 6 (2–26) 0.984
SUVpeak
 Maximum 8.7 (4.4–13.1) 13.3 (7.1–23.5) 0.011 10.1 (5.6–18.9) 8.8 (5.2–13.9) 0.310
 Median 3.9 (2.7–7.4) 5.5 (3.5–8.9) 0.203 5.3 (3.3–9.0) 4.0 (3.2–8.3) 0.317
SUVpeak interquartile ranged 1.2 (0–3.3) 3.3 (1.5–6.7) 0.002 2.7 (0–5.1) 2.0 (0–4.7) 0.380
SUVmax
 Maximum 11.3 (6.1–16.6) 15.8 (9.0–27.7) 0.026 13.0 (7.3–22.2) 11.6 (7.2–17.4) 0.344
 Median 5.3 (3.7–9.4) 8.0 (4.9–12.0) 0.171 7.4 (4.5–11.7) 5.3 (4.0–11.7) 0.394
SUVmean
 Maximum 6.0 (4.1–8.7) 9.0 (6.1–15.4) 0.009 8.4 (4.7–12.3) 6.9 (4.7–8.8) 0.274
 Median 3.9 (2.8–6.2) 5.3 (3.4–7.6) 0.128 4.8 (3.2–7.9) 3.9 (2.9–7.1) 0.256
Total MATV (ml) 14 (6–65) 127 (29–512) < 0.001 44 (10–185) 29 (13–238) 0.861
Total TLG 67 (18–448) 1180 (200–2998) < 0.001 281 (43–1541) 199 (64–1568) 0.984
  1. Data are displayed as median (interquartile range)
  2. LDH lactate dehydrogenase
  3. aOne patient had a missing LDH value
  4. bThree patients with normal LDH had only lesions < 1 ml
  5. cAll lesions included in subsequent quantitative analyses
  6. dInterquartile range of the different SUVpeaks measured within one patient, measure of intra-patient heterogeneity