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Table 3 Mean FP-CIT SPECT and FE-PE2I PET binding in HC and patients

From: Dopamine transporter imaging with [18F]FE-PE2I PET and [123I]FP-CIT SPECT—a clinical comparison

  HC, n = 28 PS, n = 22 Sig. Effect size
Mean (SD) Mean (SD) p Glass’s Δ
FP-CIT, SUR
 Caudate 3.12 (0.46) 2.35 (0.79) < 0.001 1.67
 Putamen 2.62 (0.47) 1.43 (0.68) < 0.001 2.54
 Striatum 2.80 (0.45) 1.77 (0.69) < 0.001 2.29
FE-PE2I, BPND
 Caudate 2.93 (0.46) 2.29 (0.80) 0.004 1.40
 Putamen 3.78 (0.46) 1.98 (1.07) < 0.001 3.90
 Striatum 3.40 (0.43) 2.12 (0.90) < 0.001 2.95
 SN 0.72 (0.07) 0.60 (0.10) < 0.001 1.62
FE-PE2I, SUVR
 Caudate 5.54 (0.75) 4.61 (1.28) 0.006 1.24
 Putamen 6.75 (0.83) 3.97 (1.71) < 0.001 3.36
 Striatum 6.21 (0.76) 4.26 (1.44) < 0.001 2.57
 SN 2.08 (0.12) 1.88 (0.18) < 0.001 1.67
  1. Measures of DAT availability in the caudate, putamen, striatum, and SN. Mean = averaged left and right side
  2. SUR specific uptake ratio, BPND binding potential relative to non-displaceable binding, SUVR specific uptake value ratio, HC healthy controls, PS parkinsonian syndrome, SN substantia nigra