EJNMMI Research

Table 2 Age correlation with DAT activity, measured with FP-CIT SPECT and FE-PE2I PET

From: Dopamine transporter imaging with [¹⁸F]FE-PE2I PET and [¹²³I]FP-CIT SPECT—a clinical comparison

	HC, n = 28			PS, n = 22
	All R	All p	Female/male R	All R	All p	Low DAT/normal DAT R
Caudate
FP-CIT, SUR	− 0.496	0.007	− 0.599*/− 0.360^†	− 0.354	0.107	− 0.565/− 0.396* ^†
FE-PE2I, BP_ND	− 0.577	0.001	− 0.803**/− 0.402^†	−0.569	0.006	− 0.679/− 0.965
FE-PE2I, SUVR	− 0.502	0.007	− 0.796**/− 0.295^†	− 0.546	0.009	− 0.649/− 0.970
Putamen
FP-CIT, SUR	− 0.400	0.035	− 0.543^†/− 0.161^†	− 0.207	0.355	− 0.612/− 0.544 ^†
FE-PE2I, BP_ND	− 0.540	0.003	− 0.697**/− 0.395^†	− 0.153	0.497	− 0.475 ^† /− 0.564 ^†
FE-PE2I, SUVR	− 0.430	0.022	− 0.556*/− 0.287^†	− 0.150	0.505	− 0.433 ^† /− 0.698 ^†
Striatum
FP-CIT, SUR	− 0.449	0.016	− 0.567*/− 0.280^†	− 0.267	0.230	− 0.602/− 0.496* ^†
FE-PE2I, BP_ND	− 0.588	0.001	− 0.780**/− 0.424^†	− 0.328	0.136	− 0.610/− 0.832 ^†
FE-PE2I, SUVR	− 0.480	0.010	− 0.675*/− 0.302^†	− 0.316	0.153	− 0.568/− 0.916
SN
FE-PE2I, BP_ND	0.071	0.719	0.246 ^† /− 0.117 ^†	− 0.175	0.436	− 0.333 ^† /− 0.221 ^†
FE-PE2I, SUVR	0.058	0.768	0.199^†/− 0.460^†	− 0.152	0.500	− 0.273 ^† /− 0.139 ^†

Correlations are calculated for mean DAT availability values in the respective compartments (averaged between the left and right hemispheres). Patients with low DAT n = 17, patients with normal DAT n = 5
SUR specific uptake ratio, BP_ND binding potential relative to non-displaceable binding, SUVR specific uptake value ratio, SN substantia nigra, HC healthy controls, PS parkinsonian syndrome
*Correlation is significant at the 0.05 level (two-tailed)
**Correlation is significant at the 0.01 level (two-tailed)
^†Correlation is not significant (two-tailed)

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