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Table 4 Data shown as in Table 2, separated according to molecular genetic and histologic grading

From: Voxel-wise analysis of dynamic 18F-FET PET: a novel approach for non-invasive glioma characterisation

Tumour VOI, post-filtering Parameter IDH-mut non-codel IDH-mut codel IDH-wt
II (19) III (20) IV (6) Post hoc II (24) III (15) U test II (12) III (27) IV (39) Post hoc
90% isocontour TTP 28 ± 7 24 ± 8 21 ± 11   24 ± 8 22 ± 10   22 ± 10 14 ± 5 17 ± 7  
Slope15–40 0.2 ± 1.0 − 0.4 ± 1.9 − 0.6 ± 1.3   −0.1 ± 0.6 − 0.4 ± 1.5 x   − 0.2 ± 1.3 − 1.5 ± 1.2 ∆x − 1.1 ± 1.2
TBR20–40 > 1.6 TBR5–15,max 2.9 ± 1.2 3.4 ± 1.7 4.1 ± 1.2 ° 2.9 ± 0.9 4.5 ± 2.1 * 3.2 ± 1.2 4.0 ± 1.2 4.7 ± 1.2 °
TBR5–15,mean 1.8 ± 0.4 2.0 ± 0.6 2.2 ± 0.4   1.8 ± 0.2 2.3 ± 0.6 * 2.0 ± 0.4 2.4 ± 0.4 2.4 ± 0.4 °
TBR20–40,max 2.9 ± 1.0 3.2 ± 1.4 3.7 ± 0.9   2.7 ± 0.8 4.0 ± 1.7 * 2.8 ± 1.0 3.1 ± 0.9 4.0 ± 1.0 °#
TBR20–40,mean 1.9 ± 0.3 2.1 ± 0.4 2.1 ± 0.2   1.9 ± 0.2 2.3 ± 0.5 * 1.9 ± 0.2 2.0 ± 0.2 2.2 ± 0.3 °#
BTV20–40 14 ± 14 22 ± 26 36 ± 21   16 ± 16 47 ± 42 * 17 ± 18 17 ± 19 35 ± 26 °#
PVHTBR,5–15 > 2 21 ± 23 37 ± 26 52 ± 27 ° 21 ± 20 49 ± 25 * 40 ± 30 67 ± 22 66 ± 16
PVHTBR,20–40 > 2 26 ± 22 36 ± 26 44 ± 14   24 ± 20 48 ± 27 * 27 ± 20 32 ± 21 52 ± 18 °#
PVHTTP > 30 57 ± 18 42 ± 20 34 ± 22   51 ± 19 48 ± 17 x   39 ± 32 16 ± 18 ∆x 24 ± 13 *#
PVHTTP < 15 7 ± 8 14 ± 14 23 ± 14 ° 10 ± 9 12 ± 9 x   21 ± 22 44 ± 26 ∆x 32 ± 15 *
PVHTTP < 20 17 ± 14 30 ± 20 43 ± 22 ° 22 ± 14 27 ± 15 x   36 ± 32 67 ± 25 ∆x 54 ± 18 *#
PVHSlope < 0 18 ± 15 31 ± 19 43 ± 24 ° 23 ± 12 28 ± 15 x   39 ± 29 66 ± 23 ∆x 51 ± 16 *#
TBR20–40 > 1.6, 10 mm Gauss PVHGaussTTP > 30 76 ± 22 55 ± 30 44 ± 35   69 ± 23 64 ± 25 x   49 ± 39 17 ± 27 ∆x 31 ± 20 *#
PVHGauss TTP < 20 7 ± 13 22 ± 23 36 ± 26 10 ± 12 17 ± 15 x   28 ± 33 65 ± 32 ∆x 46 ± 24 *#
PVHGauss,Slope < 0 9 ± 15 26 ± 28 42 ± 35 ° 12 ± 14 21 ± 18 x   34 ± 37 72 ± 32 ∆x 52 ± 24 *#
  1. Post hoc P < 0.05: +IDH-mut non-codel vs. IDH-mut codel, IDH-mut non-codel vs. IDH-wt, xIDH-mut codel vs. IDH-wt; WHO grade * II vs. III, ° II vs. IV, # III vs. IV