Voxel-wise analysis of dynamic 18 F-FET PET: a novel approach for non-invasive glioma characterisation

EJNMMI Research

Table 2 TTP (units: min p.i.), Slope_15–40 (units: SUV/h), TBR (units: 1), and BTV_20–40 (units: mL) from VOI-based analysis and voxel-wise PVH (units: %) separated according to histologic grading

Tumour VOI, post-filtering	Parameter	WHO II (55)	WHO III (62)	WHO IV (45)	H test P; r	Post hoc
90% isocontour	TTP	25 ± 8	19 ± 9	17 ± 8	< 0.001; 0.39	*°
90% isocontour	Slope_15–40	− 0.0 ± 0.9	− 0.9 ± 1.6	− 1.0 ± 1.2	< 0.001; 0.36	*°
TBR_20–40 > 1.6	TBR_5–15,max	2.9 ± 1.1	3.9 ± 1.6	4.6 ± 1.2	< 0.001; 0.50	*°^#
	TBR_5–15,mean	1.8 ± 0.3	2.2 ± 0.5	2.4 ± 0.4	< 0.001; 0.53	*°
	TBR_20–40,max	2.8 ± 0.9	3.4 ± 1.3	4.0 ± 1.0	< 0.001; 0.43	°^#
	TBR_20–40,mean	1.9 ± 0.2	2.1 ± 0.4	2.2 ± 0.3	< 0.001; 0.43	*°^#
	BTV_20–40	15 ± 16	26 ± 30	36 ± 25	< 0.001; 0.38	°^#
	PVH_{TBR,5–15 > 2}	25 ± 24	53 ± 27	64 ± 18	< 0.001; 0.55	*°
	PVH_{TBR,20–40 > 2}	26 ± 21	37 ± 24	51 ± 17	< 0.001; 0.43	*°^#
	PVH_TTP > 30	50 ± 23	32 ± 23	25 ± 15	< 0.001; 0.43	*°
	PVH_TTP < 15	11 ± 14	26 ± 25	31 ± 15	< 0.001; 0.47	*°
	PVH_TTP < 20	23 ± 20	45 ± 29	52 ± 18	< 0.001; 0.49	*°
	PVH_{Slope < 0}	25 ± 19	46 ± 27	50 ± 17	< 0.001; 0.47	*°
TBR_20–40 > 1.6, 10 mm Gauss	PVH_{GaussTTP > 30}	67 ± 28	41 ± 34	32 ± 23	< 0.001; 0.44	*°
	PVH_{Gauss TTP < 20}	13 ± 20	39 ± 34	44 ± 24	< 0.001; 0.51	*°
	PVH_{Gauss,Slope < 0}	16 ± 23	45 ± 36	51 ± 26	< 0.001; 0.50	*°