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Table 2 TTP (units: min p.i.), Slope15–40 (units: SUV/h), TBR (units: 1), and BTV20–40 (units: mL) from VOI-based analysis and voxel-wise PVH (units: %) separated according to histologic grading

From: Voxel-wise analysis of dynamic 18F-FET PET: a novel approach for non-invasive glioma characterisation

Tumour VOI, post-filtering Parameter WHO II (55) WHO III (62) WHO IV (45) H test P; r Post hoc
90% isocontour TTP 25 ± 8 19 ± 9 17 ± 8 < 0.001; 0.39
Slope15–40 − 0.0 ± 0.9 − 0.9 ± 1.6 − 1.0 ± 1.2 < 0.001; 0.36
TBR20–40 > 1.6 TBR5–15,max 2.9 ± 1.1 3.9 ± 1.6 4.6 ± 1.2 < 0.001; 0.50 #
TBR5–15,mean 1.8 ± 0.3 2.2 ± 0.5 2.4 ± 0.4 < 0.001; 0.53
TBR20–40,max 2.8 ± 0.9 3.4 ± 1.3 4.0 ± 1.0 < 0.001; 0.43 °#
TBR20–40,mean 1.9 ± 0.2 2.1 ± 0.4 2.2 ± 0.3 < 0.001; 0.43 #
BTV20–40 15 ± 16 26 ± 30 36 ± 25 < 0.001; 0.38 °#
PVHTBR,5–15 > 2 25 ± 24 53 ± 27 64 ± 18 < 0.001; 0.55
PVHTBR,20–40 > 2 26 ± 21 37 ± 24 51 ± 17 < 0.001; 0.43 #
PVHTTP > 30 50 ± 23 32 ± 23 25 ± 15 < 0.001; 0.43
PVHTTP < 15 11 ± 14 26 ± 25 31 ± 15 < 0.001; 0.47
PVHTTP < 20 23 ± 20 45 ± 29 52 ± 18 < 0.001; 0.49
PVHSlope < 0 25 ± 19 46 ± 27 50 ± 17 < 0.001; 0.47
TBR20–40 > 1.6, 10 mm Gauss PVHGaussTTP > 30 67 ± 28 41 ± 34 32 ± 23 < 0.001; 0.44
PVHGauss TTP < 20 13 ± 20 39 ± 34 44 ± 24 < 0.001; 0.51
PVHGauss,Slope < 0 16 ± 23 45 ± 36 51 ± 26 < 0.001; 0.50
  1. Post hoc P < 0.05: WHO grade * II vs. III, ° II vs. IV, # III vs. IV