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Table 1 Overview of dosimetry methods

From: Dosimetry methods and clinical applications in peptide receptor radionuclide therapy for neuroendocrine tumours: a literature review

Method Assumptions Advances Drawbacks Clinical application
Monte Carlo simulation Simulation of certain number of particles. Manual particle energy cut-off values Very accurate, includes tissue density heterogeneities and cross-fire dose Many simulation parameters. Long-calculation times Not applicable for clinical routine. Calculation of S values and dose kernels
S values Homogeneous radioactivity distribution in tissue Fast, easy, commonly used and generally accepted Based on reference phantoms, mean absorbed dose per tumour or organ Organs and lesions without superimposition. Toxicity studies
Dose kernels Homogeneous radioactivity distribution within one voxel, infinite homogeneous tissue density DVH and isodose lines, patient-specific Calculated for each radionuclide, not tissue specific. Mean absorbed dose per voxel Patient-specific voxel-based tumour and normal tissue dosimetry
Local energy deposition All energy is absorbed in the source voxel Fast Not suitable for photons Primarily for β- and α-emitters