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Table 3 Immunohistochemical assessment for CXCR4 in surgical specimens

From: PET imaging of chemokine receptor CXCR4 in patients with primary and recurrent breast carcinoma

Patient # Subtype Immune cells Immune cell positivity (%) Tumor cells Tumor cell positivity (%) Overall signal strength SUVmax
3 ILC + 0 0 1.7
5 NST +++ 40 ++ 15 ++ 2.9
6 NST ++ 5 ++ 5 + 1.9
7 NST ++ 10 +++ 2 + 2.8
8 NST + 5 + 0 3.2
10 ILC 0 + 20 + 1.8
11 NST +++ 20 + 20 ++ 1.8
  1. Degree of immune cell infiltration was scored from (−) (no infiltration) to (+++) (strong infiltration). Staining intensity for tumor cells was scored from (−) (no expression) to (+++) (strong expression). Percentage amount of CXCR4-positive immune and tumor cells in the specimens (positivity) is shown in the third and fifth columns. The last columns show overall signal intensity and corresponding SUVmax during PET CXCR4-directed PET imaging respectively