Fig. 5
From: Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate
Therapy study with antibody-drug-conjugate, IMGN853, and companion diagnostic, [89Zr]Zr-DFO-M9346A, using OV90 xenografts. a Overall design of the therapy study including inoculation of cancer cells, injection of ADC and companion diagnostic, PET imaging after 2 days, and continuously measuring tumor growth. b PET images of mice injected with [89Zr]Zr-DFO-M9346A (90.3 ± 1.1 μCi, 25 μg) and IMGN853 (1.25 mg/kg, 31.2 μg) and quantification through ROI analysis of coronal slices. c Plot of the individual tumor volume post treatment (days). d Correlation of tracer uptake (%IA/g) and therapy outcome