Fig. 4
From: Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate
Pharmacokinetic head-to-head comparison between antibody-drug-conjugate, IMGN853 and companion diagnostic, [89Zr]Zr-DFO-M9346A. a Introduction of the radionuclide I-131 by direct halogenation of the antibody in the presence of Iodogen as chemical oxidant yielding radiolabeled antibody-drug-conjugate [131I]-IMGN853 (32.2 MBq, 0.87 mCi, 250 μg) in high radiochemical purity (> 98%). b In vitro characterization of [131I]-IMGN853. Incubation of KB cells with radiolabeled ADC or with a mixture of radiolabeled ADC (100 ng) and M9346A (10 μg). c Comparison of blood half-lives of [131I]-IMGN853 and [89Zr]Zr-DFO-M9346A (dashed line indicates the 95% confidence band)