Table 3 Percentage of intact 213BiIII chelates after incubation at 37 °C with 0.1 M aq. sodium DTPA (pH 7.5) or human plasma. Data represent mean values ± SD, n = 3
medium | t [min] | DOTP | DOTPH | DOTPOEt | DOTPI | CHX-A"-DTPA | DOTA |
|---|---|---|---|---|---|---|---|
DTPA | 30 | 97.3 ± 0.9 | 98.1 ± 0.8 | 94.6 ± 1.3 | 93.5 ± 0.6 | 92.5 ± 1.1 | 91.1 ± 2.4 |
DTPA | 60 | 87.0 ± 7.9 | 87.1 ± 7.7 | 86.8 ± 6.3 | 83.3 ± 3.9 | 82.7 ± 8.1 | 83.4 ± 9.0 |
DTPA | 120 | 69.9 ± 4.5 | 73.4 ± 1.2 | 71.0 ± 4.6 | 72.3 ± 5.4 | 55.6 ± 2.2 | 64.1 ± 2.1 |
Plasma | 60 | 98.4 ± 1.6 | 99.2 ± 0.5 | 98.8 ± 0.8 | 95.6 ± 1.9 | 90.8 ± 4.6 | 96.1 ± 4.0 |
Plasma | 120 | 96.4 ± 1.3 | 97.0 ± 1.8 | 97.2 ± 1.9 | 91.1 ± 7.1 | 76.3 ± 9.4 | 85.4 ± 4.3 |