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Table 3 Percentage of intact 213BiIII chelates after incubation at 37 °C with 0.1 M aq. sodium DTPA (pH 7.5) or human plasma. Data represent mean values ± SD, n = 3

From: Efficient formation of inert Bi-213 chelates by tetraphosphorus acid analogues of DOTA: towards improved alpha-therapeutics

medium t [min] DOTP DOTPH DOTPOEt DOTPI CHX-A"-DTPA DOTA
DTPA 30 97.3 ± 0.9 98.1 ± 0.8 94.6 ± 1.3 93.5 ± 0.6 92.5 ± 1.1 91.1 ± 2.4
DTPA 60 87.0 ± 7.9 87.1 ± 7.7 86.8 ± 6.3 83.3 ± 3.9 82.7 ± 8.1 83.4 ± 9.0
DTPA 120 69.9 ± 4.5 73.4 ± 1.2 71.0 ± 4.6 72.3 ± 5.4 55.6 ± 2.2 64.1 ± 2.1
Plasma 60 98.4 ± 1.6 99.2 ± 0.5 98.8 ± 0.8 95.6 ± 1.9 90.8 ± 4.6 96.1 ± 4.0
Plasma 120 96.4 ± 1.3 97.0 ± 1.8 97.2 ± 1.9 91.1 ± 7.1 76.3 ± 9.4 85.4 ± 4.3