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Table 1 Percentage of incorporation of 213BiIII by chelate ligands (pH 5.5, V = 0.1 mL, reaction time 5 min at 25 °C). Data represent mean values ± SD, n = 3

From: Efficient formation of inert Bi-213 chelates by tetraphosphorus acid analogues of DOTA: towards improved alpha-therapeutics

c [μM] DOTP DOTPH DOTPOEt DOTPI CHX-A"-DTPA DOTA
100 92.9 ± 5.6 91.6 ± 0.4 79.6 ± 3.6 84.8 ± 4.0 91.4 ± 5.1 61.0 ± 7.3
30 88.8 ± 10.7 83.8 ± 11.9 70.8 ± 8.8 70.6 ± 11.9 78.6 ± 6.9 37.4 ± 6.9
10 87.2 ± 11.8 82.5 ± 12.4 70.6 ± 6.5 61.5 ± 5.1 75.7 ± 11.8 15.6 ± 6.7
3 86.5 ± 11.2 80.4 ± 9.7 66.0 ± 9.5 58.1 ± 2.4 75.3 ± 12.6 11.2 ± 0.9
1 89.3 ± 7.2 78.4 ± 10.6 63.5 ± 11.2 47.9 ± 2.6 66.6 ± 20.6 5.1 ± 4.6
0.3 85.4 ± 2.5 75.0 ± 14.8 56.0 ± 9.9 27.0 ± 2.0 41.5 ± 8.5
0.1 85.0 ± 5.2 66.7 ± 3.1 42.4 ± 13.2 15.4 ± 9.5 22.1 ± 10.1
0.03 67.6 ± 3.5 42.2 ± 2.8 27.5 ± 11.2 11.8 ± 3.5
0.01 32.4 ± 4.6 20.2 ± 5.7 16.7 ± 6.4
0.003 13.6 ± 4.1 3.8 ± 0.9 6.6 ± 3.5
0.001 4.3 ± 1.6 0.9 ± 1.3