Fig. 1

a MIP and b cardiac bed images from participant #2 show intense myocardial ¹⁸F-florbetaben uptake, suspicious for amyloid. Intense uptake was also demonstrated in the extraocular muscles, consistent with recent orbital MRI findings that were concerning for amyloid involvement (c). Although such manifestation is rare, intense uptake was noted in the thyroid glands (d). The patient had mild or subclinical hypothyroidism, with low free thyroxine (1.1μg/dl) and upper limit of the TSH normal range (3.85–4.6 mIU/L). Physical examination of the neck also revealed discomfort on palpation