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Table 2 Rate constants obtained using a 2T3k_VB model and three different plasma input functions (IF) for all subjects

From: First in human evaluation of [18F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors

  Single scan IF Within-subject IF Population IF
  Preferred model K 1 V ND k 3 K i Ki TRTV Preferred model K i Ki TRTV Preferred model K i Ki TRTV
S1 Test 2T3k 0.522 9.64 0.0016 0.0148 − 32% 2T3k 0.0118 6% 2T3k 0.0136 4%
Retest 2T3k 0.420 8.02 0.0014 0.0108 2T3k 0.0126 2T3k 0.0142
S2 Test 2T4k 0.577 10.12 0.0016 0.0157 − 23% 2T3k 0.0131 -3% 2T3k 0.0113 18%
Retest 2T3k 0.407 5.90 0.0022 0.0125 2T3k 0.0127 2T3k 0.0136
S3 Test 2T3k 0.341 7.33 0.0024 0.0166 − 9% 2T3k 0.0154 5% 2T3k 0.0193 4%
Retest 2T4k 0.347 6.14 0.0026 0.0152 2T4k 0.0162 2T4k 0.0201
S4 Test 2T3k 0.473 9.73 0.0025 0.0235 − 45% 2T3k 0.0202 − 17% 2T3k 0.0147 −24%
Retest 2T3k 0.490 9.34 0.0016 0.0148 2T3k 0.0170 2T3k 0.0115
S5 Test 2T3k 0.451 8.64 0.0025 0.0208 − 14% 2T3k 0.0200 − 5% 2T3k 0.0170 −9%
Retest 2T3k 0.465 7.29 0.0026 0.0182 2T3k 0.0191 2T3k 0.0156
Mean TRTV 13% 21% 20% 24.3% ± 14.5 7.3% ± 5.6 11.9% ± 8.9
Mean test 0.473 9.09 0.0021 0.0183 0.0161 0.0152
Mean retest 0.426 7.34 0.0021 0.0143 0.0155 0.0150
  Preferred model K 1 V ND k 3 K i % ΔKi Preferred model K i % ΔKi Preferred model K i % ΔKi
S6 Baseline 1T2k 0.528 9.78 0.0005 0.0046 182% 1T2k 0.0038 237% 2T4k 0.0071 113%
Ketamine 2T3k 0.605 9.66 0.0014 0.0129 2T3k 0.0128 2T3k 0.0152
S7 Baseline 2T4k 0.394 6.54 0.0029 0.0182 − 35% 2T4k 0.0170 0% 2T4k 0.0150 8%
Ketamine 2T3k 0.487 9.75 0.0012 0.0118 2T3k 0.0169 2T4k 0.0162
S8 Baseline 2T3k 0.683 11.72 0.0007 0.0083 1% 2T3k 0.0220 − 9% 2T3k 0.0183 −9%
Ketamine 2T4k 0.559 10.30 0.0008 0.0084 2T3k 0.0201 2T3k 0.0167
S9 Baseline 2T3k 0.368 7.74 0.0026 0.0193 − 36% 2T3k 0.0200 − 41% 2T3k 0.0114 −62%
Ketamine 2T4k 0.328 6.56 0.0020 0.0124 2T3k 0.0118 2T3k 0.0044
S10 Baseline 2T3k 0.488 10.51 0.0014 0.0143 30% 2T3k 0.0105 83% 1T2k 0.0011 −10%
Ketamine 2T3k 0.600 9.84 0.0020 0.0186 2T3k 0.0192 1T2k 0.0010
Mean baseline 0.492 9.25 0.0016 0.0129    0.0147    0.0106  
Mean ketamine 0.516 9.22 0.0015 0.0128    0.0162    0.0107  
% Change 5% 0% −9% −1%    10%    1%  
  1. The unit of K1 is mL · cm3 · min−1 and the unit of k3 and Ki is min−1. VND equals K1/k2
  2. TRTV test–retest variability, %ΔKi the percentage change from the baseline scan