First in human evaluation of [18F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors

EJNMMI Research

Table 1 Subject demographics and injectate details

	Subject	Gender	Weight (kg)	Age	Scan interval (days)	Injected activity PET1 (MBq)	Injected activity PET2 (MBq)	A_m PET1 (MBq · nmol⁻¹)	A_m PET2 (MBq · nmol⁻¹)	Mass PET1 (μg)	Mass PET2 (μg)
Test–retest group	1	F	70	37	47	191	185	41	87	1.6	0.8
	2	M	86	23	35	185	176	87	123	0.8	0.5
	3	M	62	23	28	187	185	88	77	0.7	0.8
	4	F	71	34	61	180	183	45	50	1.4	1.3
	5	M	93	22	31	173	172	60	64	1.0	1.0
	Mean					183	180	64	80	1.1	0.9
	SD					7	6	22	28	0.4	0.3
	Paired t test (P value)					0.23		0.21		0.22
Ketamine group	6	F	64	23	161	191	194	47	17	1.4	4.1
	7	M	83	28	28	189	187	89	44	0.8	1.5
	8	F	56	23	98	187	188	80	38	0.8	1.7
	9	M	81	23	49	202	195	52	56	1.4	1.2
	10	F	70	25	13	189	195	10	40	6.4	1.7
	Mean					192	192	56	39	2.2	2.1
	SD					6	4	31	14	2.4	1.1
	Paired t test (P value)					0.92		0.31		0.94