Fig. 2

PET/CT images performed for re-staging in patient #14. Transaxial ¹⁸F-FDG (a) and ⁶⁸Ga-somatostatin analogs (b, c) at different intensity levels. PET/CT images showed abnormal tracer uptake in both adrenal metastatic lesions (red arrows). Both adrenals were enlarged (right > left). The pattern of uptake was inhomogeneous with both ¹⁸F-FDG and ⁶⁸Ga-somatostatin analogs and, in the whole, a “reverse” and complementary distribution of uptake was evident with the two tracers, with clearly parts of the tumor that take up one or the other tracer (e.g., the “hottest” part of the right adrenal at ¹⁸F-FDG appears substantially “cold” at ⁶⁸Ga-SRI)